Publication

array(14 items)
   uid => 893 (integer)
   title => 'Defining the landscape of circular RNAs in neuroblastoma unveils a global su
      ppressive function of MYCN' (102 chars)
   abstract => 'Circular RNAs (circRNAs) are a regulatory RNA class. While cancer-driving fu
      nctions have been identified for single circRNAs, how they modulate gene exp
      ression in cancer is not well understood. We investigate circRNA expression 
      in the pediatric malignancy, neuroblastoma, through deep whole-transcriptome
       sequencing in 104 primary neuroblastomas covering all risk groups. We demon
      strate that  MYCN amplification, which defines a subset of high-risk cases, 
      causes globally suppressed circRNA biogenesis directly dependent on the DHX9
       RNA helicase. We detect similar mechanisms in shaping circRNA expression in
       the pediatric cancer medulloblastoma implying a general MYCN effect. Compar
      isons to other cancers identify 25 circRNAs that are specifically upregulate
      d in neuroblastoma, including circARID1A. Transcribed from the  ARID1A tumor
       suppressor gene, circARID1A promotes cell growth and survival, mediated by 
      direct interaction with the KHSRP RNA-binding protein. Our study highlights 
      the importance of MYCN regulating circRNAs in cancer and identifies molecula
      r mechanisms, which explain their contribution to neuroblastoma pathogenesis
      .' (1141 chars)
   authors => array(30 items)
      0 => array(3 items)
         last_name => 'Fuchs' (5 chars)
         first_name => 'Steffen' (7 chars)
         sorting => 1 (integer)
      1 => array(3 items)
         last_name => 'Danßmann' (9 chars)
         first_name => 'Clara' (5 chars)
         sorting => 2 (integer)
      2 => array(3 items)
         last_name => 'Klironomos' (10 chars)
         first_name => 'Filippos' (8 chars)
         sorting => 3 (integer)
      3 => array(3 items)
         last_name => 'Winkler' (7 chars)
         first_name => 'Annika' (6 chars)
         sorting => 4 (integer)
      4 => array(3 items)
         last_name => 'Fallmann' (8 chars)
         first_name => 'Jörg' (5 chars)
         sorting => 5 (integer)
      5 => array(3 items)
         last_name => 'Krützfeldt' (11 chars)
         first_name => 'Louisa Marie' (12 chars)
         sorting => 6 (integer)
      6 => array(3 items)
         last_name => 'Szymansky' (9 chars)
         first_name => 'Annabell' (8 chars)
         sorting => 7 (integer)
      7 => array(3 items)
         last_name => 'Naderi' (6 chars)
         first_name => 'Julian' (6 chars)
         sorting => 8 (integer)
      8 => array(3 items)
         last_name => 'Bernhart' (8 chars)
         first_name => 'Stephan H.  F.' (14 chars)
         sorting => 9 (integer)
      9 => array(3 items)
         last_name => 'Grunewald' (9 chars)
         first_name => 'Laura' (5 chars)
         sorting => 10 (integer)
      10 => array(3 items)
         last_name => 'Helmsaür' (9 chars)
         first_name => 'Konstantin' (10 chars)
         sorting => 11 (integer)
      11 => array(3 items)
         last_name => 'Rodrigüz Fos' (13 chars)
         first_name => 'Elias' (5 chars)
         sorting => 12 (integer)
      12 => array(3 items)
         last_name => 'Kirchner' (8 chars)
         first_name => 'Marieluise' (10 chars)
         sorting => 13 (integer)
      13 => array(3 items)
         last_name => 'Mertins' (7 chars)
         first_name => 'Philipp' (7 chars)
         sorting => 14 (integer)
      14 => array(3 items)
         last_name => 'Astrahantseff' (13 chars)
         first_name => 'Kathy' (5 chars)
         sorting => 15 (integer)
      15 => array(3 items)
         last_name => 'Sünkel' (7 chars)
         first_name => 'Christin' (8 chars)
         sorting => 16 (integer)
      16 => array(3 items)
         last_name => 'Todling' (7 chars)
         first_name => 'Jorn' (4 chars)
         sorting => 17 (integer)
      17 => array(3 items)
         last_name => 'Meggetto' (8 chars)
         first_name => 'Fabienne' (8 chars)
         sorting => 18 (integer)
      18 => array(3 items)
         last_name => 'Remke' (5 chars)
         first_name => 'Marc' (4 chars)
         sorting => 19 (integer)
      19 => array(3 items)
         last_name => 'Stadler' (7 chars)
         first_name => 'Peter Florian' (13 chars)
         sorting => 20 (integer)
      20 => array(3 items)
         last_name => 'Hundsdorfer' (11 chars)
         first_name => 'Patrick' (7 chars)
         sorting => 21 (integer)
      21 => array(3 items)
         last_name => 'Deubzer' (7 chars)
         first_name => 'Hedwig E.' (9 chars)
         sorting => 22 (integer)
      22 => array(3 items)
         last_name => 'Künkele' (8 chars)
         first_name => 'Annette' (7 chars)
         sorting => 23 (integer)
      23 => array(3 items)
         last_name => 'Lang' (4 chars)
         first_name => 'Peter' (5 chars)
         sorting => 24 (integer)
      24 => array(3 items)
         last_name => 'Fuchs' (5 chars)
         first_name => 'Jörg' (5 chars)
         sorting => 25 (integer)
      25 => array(3 items)
         last_name => 'Henssen' (7 chars)
         first_name => 'Anton G.' (8 chars)
         sorting => 26 (integer)
      26 => array(3 items)
         last_name => 'Eggert' (6 chars)
         first_name => 'Angelika' (8 chars)
         sorting => 27 (integer)
      27 => array(3 items)
         last_name => 'Rajewsky' (8 chars)
         first_name => 'Nikolaus' (8 chars)
         sorting => 28 (integer)
      28 => array(3 items)
         last_name => 'Hertwig' (7 chars)
         first_name => 'Falk' (4 chars)
         sorting => 29 (integer)
      29 => array(3 items)
         last_name => 'Schulte' (7 chars)
         first_name => 'Johannes H.' (11 chars)
         sorting => 30 (integer)
   type => '0' (1 chars)
   keywords => 'General Physics and Astronomy, General Biochemistry, Genetics and Molecular 
      Biology, General Chemistry, Multidisciplinary' (121 chars)
   year => 2023 (integer)
   affiliation => 0 (integer)
   link_paper => 'https://www.nature.com/articles/s41467-023-38747-4.pdf' (54 chars)
   link_supplements => '' (0 chars)
   file_published => 0 (integer)
   journal => 'Nature Communications' (21 chars)
   doi => '10.1038/s41467-023-38747-4' (26 chars)
   preprint => '-1' (2 chars)