CLUSTAL 2.0.9 multiple sequence alignment Haemonchus -----------------------------------------SFDKALCEN---------- Ancyclostoma ------------------------------------GVRREKGDHVFTATRVGTRSEARI elegans ------------------------------------------------------------ remanei ------------------------------------------------------------ brenneri ------------------------------------------------------------ briggsae ------------------------------------------------------------ japonica ------------------------------------------------------------ Brugia MTATVVDQPDKQQNQQQDQEHTSKQHLSEQLQPEHDIIIASMEGTDDEVAVAVLRDISTD Ascaris ------------------------------------------------------------ Trichinella ------------------------------------------------------------ Haemonchus -SHSAMTLSERPTVVPHTSDQERSVSDGDLETEKKRRKTRRRRANKSRFKPYHSLSPEEK Ancyclostoma EVYSAMASKELPSVARPD-DHERSISDGDVELEKKRRKTRRR-ANKNRFKPYHSLSPEEK elegans -----MADYYGLFTSD-----TRSVSDGES-DGERRLRRSRRKRGGGRFRPYSPDYSDDE remanei -----MADYYGLFASE-----ARSVSDGES-DGERRLRRSRRKRGGGRYRPYSPGNSDEE brenneri -----MADYYGLLASET----ARSLSDGES-DSERRLRRSRRKRGAVRARPYSPGNSNSD briggsae -----MAAESSSDNFELS---ARSVSDGES-DGERRLRRSRRKRGG-RYRPYSP-----D japonica -----MAEMPAR---------SMSASDGESSDAERRLRRSRRKRGGQRVRPYAISPENFA Brugia ESYQTTVENDPKNEQNYSGRIPDHGVLSASSSHAKTKKSRRRRGGKGRWKPYRTSLKEKI Ascaris ------------------------------------------------------------ Trichinella ----------SSNVVEQP---AGVMISSLRRQRRPKRKKRTRRQVRRPWKPYFKLSLEER Haemonchus IALDAAETARSERRIRERXXXMANGKPMAPSNTTQFLLEDREARAEKGLEXXXVELAYEA Ancyclostoma MALDAAETARSERRTREH---MAHGKPMAPSNTTQFLLEDREARAEQGLE---VELAHEE elegans KTKPTKKNQK--------RPDKQDRFGMAPPNSTQFLLEDREARADAEFE---NEQKFEA remanei TAKDFDKKQKN------KRAEKPDRFGMAPPNSTQFLLDDREARADAEFE---NEQRFEA brenneri DDEQQLKQKK--------NAYRSDRYGMAPPNSTQFLLDDREARADAELE---AEQKFEA briggsae AEQKVDKKNR--------KADKQDRYGMAPPNSTQFLLDDREARADAEYE---IEQKFEA japonica VEKKPVNKRK-----------LRDRRGMAPPNSTQFLLDDREERANAEYE---NEQKFEA Brugia AQEEKEERNAVEK----RERLFSRGKPMAPYNTTQFLVEDHEKRTMPPDVSD-SLPAMVA Ascaris -------------------TLFCRVRLLS------------------------------- Trichinella QRLELREERRAER---IRAQRFAHGLPVAPYNTTQFLLDDREARESEPICVD--EIVDTI :: Haemonchus SERKRVRSISVSSEFMAAS------------------------------------EGASS Ancyclostoma SERRRVRSISVSSEFMAAS------------------------------------EGASS elegans AERRRVRTMSGSYEHMRP--AYWCTIEPATTTADFGSDDN-----------NDLDS---T remanei AERRRVRTMSGSYDHMRP--AYWCTIEPATTTTYHDDDDR-----------HDVDSGSSS brenneri AERRRVRTMSGSYEHMRPS-AYWCTIEPAHTTTASTPSTTNEAAPGYVVEPEDVADNSSC briggsae SERRRVRTMSGSYDHMRP--AYWCTVEPATTTTVALEDHED----------VESVSTSCC japonica AERRRIRSLSGSFEQMRHAFSGATTIEPATTTTTIASTACGSGSG------CGTDAEESV Brugia HQRQSTGVFSPARERCGTI----------------------------GQSGSEMGGNTTD Ascaris --------------------------------------------------GSDPGGNTSE Trichinella RHEGAVNDHHGHTKHVPNHHHHHHS------------------------DHMVGDEYSSD Haemonchus SGDS--ETDKEMVREFEADFEEYTMDRISKLHKDGVXXXILDKEKNAELYQENMSKMMKE Ancyclostoma SGDS--ETDKEMDREFEAEFEEYTMDRLSRLTKDEMTREILDKEKNAELYQENMSRMMKE elegans SGES--EADREMEREFETDYLEVKRERIQSMTRSQLAAELLERDQDTQVLTRELGSKETE remanei SGES--EADREMEREFETDYLEVKRERIQSMTKSQLAAELLERDQDTQQLARELGSKESE brenneri SGSS--CSDREMEREFENEYLEVKRERIQSMTRSQLAAELLERDQDTQLLARELGSKESE briggsae SDESEAAADREMEREFESDYQASKRERIQSMTKSQLAAELLERDQDTQELTRELGTKESE japonica SGES--EADREMEREFETDYLEVKRERIQSMTRSQLAQELLERDQDTQLLTQELDTMDAE Brugia SASYSGAEDDEMERQFDADYDYVNMERISNMTKDDVAREYMHLEKINGKLADRVSFLQLE Ascaris SGSVSGEEGERLEREFDAEYDSVNLMRISGMSREEVSSIHQCLHFILFMCAHRST----- Trichinella SVTTSEGDLCMLEREFDYEYETAHAERLEEMSKEQLVQEYIHLEKELERYQSESAQLRSA * : *:*: :: *:. : :. : . . Haemonchus NQRLRKMLIDNGIVLGENHTSQSVV------------------------- Ancyclostoma NQRLRKMLQDNGIPVDHNHTSQPVV------------------------- elegans NRHLRSLLSAHGISPDEPVTSTTAI----VVGQSKSPVVAN--------- remanei NQHLRKLLYAHGISPDEPVTSTTTID---VVVGSKSPVIAN--------- brenneri NRHLRNLLSAHGISPDEPVSSTTSS----IGNVSKSPVIAN--------- briggsae NRHLRKLLTAHGISPDEPVTSSTTALQLNAVSASKSPVIAN--------- japonica NRHLRRLLTAHGIHLESPPDDVTSSG---APCVDKSPVIA---------- Brugia NDKLKQXLKDXNISYEDVLPKIRRHSGTSVSEAGDVVRKSVDEAMGNGRQ Ascaris -------------------------------------------------- Trichinella VSELAKRCSTCGHNDVTPPPPPPQLVGLADGEEHQQNGHST---------