CLUSTAL 2.0.9 multiple sequence alignment Lottia ------------------------------------------------------------ Crassostrea ------------------------------------------------------------ Saccoglossus ------------------------------------------------------------ Ciona_intestinalis ------------------------------------------------------------ Ciona_savignyi ------------------------------------------------------------ Hydra ------------------------------------------------------------ Nematostella ------------------------------------------------------------ Capitella ------------------------------------------------------------ Branchiostoma ------------------------------------------------------------ Taeniopygia ------------------------------------------------------------ Gallus ------------------------------------------------------------ Anolis ------------------------------------------------------------ H1_Bos ------------------------------------------------------------ H1_Sus ------------------------------------------------GLNSQNSSNFEK H1_Pan ------------------------------------------------------------ H1_Homo ------------------------------------------------------------ H1_Pongo ----------------------------------------------------------TS H1_Macaca ------------------------------------------------------------ H1_Canis -------------------------------------------------GLTAKIYKLRE H1_Felis ------------------------------------------------------------ H1_Equus ------------------------------------------------------------ H1_Erinaceus ------------------------------------------------------------ H1_Microcebus ------------------------------------------------------------ H1_Otolemur ------------------------------------------------------------ H1_Myotis ------------------------------------------------------------ H1_Rattus ------------------------------------------------------------ H1_Mus ------------------------------------------------------------ H1_Ochotona -----------------------------------------------------HLSNLDK H1_Oryctolagus --------------------------------TLGHLQREKRKSFFPSRIQSQHFANFEK H1_Monodelphis ------------------------------------------------------------ H1_Sorex ------------------------------------------------------------ H1_Cavia ------------------------------------------------------------ Ornithorhynchus ------------------------------------------------------------ H2_Bos ------------------------------------------------------------ H2_Canis ------------------------------------------------------------ H2_Equus ------------------------------------------------------------ H2_Erinaceus ------------------------------------------------------------ H2_Homo ------------------------------------------------------------ H2_Pan ------------------------------------------------------------ H2_Pongo ------------------------------------------------------------ H2_Macaca ------------------------------------------------------------ H2_Microcebus ------------------------------------------------------------ H2_Dasypus ------------------------------------------------------------ H2_Myotis ------------------------------------------------------------ H2_Rattus ------------------------------------------------------------ H2_Mus ------------------------------------------------------------ H2_Felis ------------------------------------------------------------ H2_Ochotona ------------------------------------------------------------ H2_Oryctolagus ------------------------------------------------------------ H2_Spermophilus ------------------------------------------------------------ H2_Tupaia ------------------------------------------------------------ H2_Loxodonta ------------------------------------------------------------ H2_Otolemur ------------------------------------------------------------ H2_Echinops ------------------------------------------------------------ H2_Sorex ----------------------------------------------------AECAIVAG H2_Monodelphis ------------------------------------------------------------ Tetraodon --------------------------------------MTEPAEETHHRETSGSPSGGIG Takifugu --------------------------------------MTEPTEQTHHLKTSDSPSGGIG Gasterostreus --------------------------------------MTEPVQQTHHPKTPGSPSGGSA Oryzias --------------------------DVLKRSFRKITIMTEPMEESHQLESLGCPSGESR Danio ------------------------------------------------------------ Xenopus_laevis ------------------------------------------------------------ Xenopus_tropicalis ------------------------------------------------------------ Callorhinchus ------------------------------------------------------------ Petromyzon ------------------------------------------------------------ Strongylocentrotus ------------------------------------------------------------ Ixodes KGVRATEIIEVIRIYANKDRKRVETVASRIGTTFWSARSGGDKTHQTGRRTGSERISALH Trichinella ------------------------------------------------------------ D_sechellia ------------------------------------------------------------ D_simulans ------------------------------------------------------------ D_erecta ------------------------------------------------------------ D_yakuba ------------------------------------------------------------ D_melanogaster ------------------------------------------------------------ D_ananassae ------------------------------------------------------------ D_persimilis ------------------------------------------------------------ D_pseudoobscura ------------------------------------------------------------ D_willistoni ------------------------------------------------------------ D_grimshawi ------------------------------------------------------------ D_virilis ------------------------------------------------------------ D_mojavensis ------------------------------------------------------------ Bombyx ------------------------------------------------------------ Phlebotomus ------------------------------------------------------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex ------------------------------------------------------------ Nasonia_vitripennis ----------------------------------------------------------SA Nasonia_girault ------------------------------------------------------------ Apis ---------------------------------------------------------MSA Acyrthosiphon ------------------------------------------------------------ Tribolium -----------------------------------------------MAHKSSHGPSPNG Pediculus ------------------------------------------------------------ Brugia ------------------------------------------------------------ Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Aplysia ------------------------------------------------------------ Reniera ------------------------------------------------------------ Trichoplax ------------------------------------------------------------ Lottia ---------------------------------------------QFSMMTMAESLMVEI Crassostrea ---------------------------------------------TISTLTLKKKNFHST Saccoglossus --------------------------------VHSVLSPTNSPTVDFVKFSLRLRSTHRG Ciona_intestinalis ------------------------------------------------------------ Ciona_savignyi ------------------------------------------------------------ Hydra ----------------------------------------MTQECIDLKVVLEIPWGLN- Nematostella ----------------------------------------TMTEEPDPSSITEVDQSTMD Capitella ----------------------------------------RIRATLLLEGFISLCKLCVY Branchiostoma ------------------------------------NSADFHGSGRFLLAFMLPREQLAT Taeniopygia ------------------------------------------------------------ Gallus --------------MADAERAP-------EAAPADPEPERGEAQTDGESG----RLPPPE Anolis ------FDNKFEPAMADVAVSSSQQQPNGKSSPVSLCLGAGGGDGDGDGGGPFLASPPSN H1_Bos -----MAEPLLSEFQHQPQTSNCTGAVAVHEERNPDRPPGAEERVPEEDSRWQSRASPKS H1_Sus RILLAMDEPLLSEYQHQPQTSNCTGAAAVHEERNPDRPPGAEERVPEEDSRWQSRASPQS H1_Pan -----MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQL H1_Homo -----MAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQL H1_Pongo RTLLAMAEPFLSEYQHQPQTSNCTGAAAVQEELNPERPPGAEERVPEEDSRWQSRAFPQL H1_Macaca -----MAEPFLSEYQHQPQTSNCTGAAAVQEEPNPERPPGAEERVPEEDSRWQSRAFPQL H1_Canis EDSISHGRATLIRIQHQPQTSNCTGAVAVHDERNPDRPPGAEERVPEEDSRWQSRASPQS H1_Felis ------------------------------------------------------------ H1_Equus -----MAEPLLSEYQHQPQTSNCTGAAAVHEERNPDRPPGAEERVPKEDSRWQSRASPKS H1_Erinaceus ------------------------------------------------------------ H1_Microcebus -----MAEPLLSEYQHQPQTSNCTGAAVVHEDRNPERPPGAEERVPEEDSRWQSRASPQP H1_Otolemur -----MAEPLLSEYQHQPQTSNYTGAAVVHEERNPERPPGAEERVLEEDSRWQSRASPQS H1_Myotis -----MAEPLVSEFQHQPQTGNCAGADAVQEERNPDRPPGAEEPVPQDDSRWQARALPQP H1_Rattus -----MAEPLLSEHQHQPQTSNCTGAAVVHEEQNSERPPSAEERVPKEDSRWQSRASLQS H1_Mus -----MAEPLLTEHQHQPQTSNCTGAAVVHEEHTSERPPSAEERVPKEDSRWQSRASLQS H1_Ochotona RTPLAMAESLLSEYQHQPQTSNCTGAAVVPGE-NAECAPGAEERVPAEDSRWQSRASPES H1_Oryctolagus RTPLAMAEPLLSEYQHQPPTSNCTGAAVVREEQKPERPPGAEERVPEEDSRWQSRAAPQP H1_Monodelphis ----------MAECQQQQQTSQTS-----SNCTGAMGRAERYTEPPGEDCRWQSRASSEL H1_Sorex ------------------------------------------------------------ H1_Cavia ----------------------XX-----XXXAADAGASE-------GDGRWRSRAS--- Ornithorhynchus ----------MRSGRLTALSAKRQAGGPLGAAGAAGSCSSRDVAVDRKRSRAFLTLPLQG H2_Bos ----------------------VNREGFHHWGEAVCDPSSFVLSLQISGTCG-SPRTS-- H2_Canis ----------------------------------------------TPGAPG-SPQTP-- H2_Equus ----------------------------------------------TSGTPG-SPTTR-- H2_Erinaceus ----------------------------------------------SPGVPE-SPGTP-- H2_Homo ------------------------MMATPNQTACNAESPVALEEAKTSGAPG-SPQTP-- H2_Pan --MALWCKRGVTSSRRLLKDLERKMMATPNQTACNAESPVALEEAKTSGAPG-SPQTP-- H2_Pongo ----------------------------------------------TSDAPG-SPQTP-- H2_Macaca ----------------------------------------------TSGAPG-SPQTP-- H2_Microcebus ----------------------------------------------TFSAPG-SPKTL-- H2_Dasypus --------------------------------------SLLSCPFQGSGAPG-SPATP-- H2_Myotis ----------------------------------------------ASDSSR-SPETP-- H2_Rattus ----------------------------------------------TSGGLR-SPQIA-- H2_Mus -------------------------MATVNHTNCNTASPAALEEAKTSGGLR-SPQIA-- H2_Felis ----------------------------------------------TPGAPG-SPQTP-- H2_Ochotona ----------------------------------------------SSGTPLGSPKMS-- H2_Oryctolagus --------------------LENDHVSWVGEGGPQAGWAEKGFGPRPSVTPAPSSLLSRP H2_Spermophilus ----------------------SSKCLKRPSSIPGVSSSPSSFRQYLWXXXXXXXXXX-- H2_Tupaia ------------------------------------------------------------ H2_Loxodonta -------------------------------------SFAFVLSLQSFRAPG-SPETP-- H2_Otolemur ----------------------------------------------TFSAPG-SPRTS-- H2_Echinops ------LAMGTVASGSEERASFCPKAR---AAVIPPPCPNPCLSLQSSGAPG-SPETP-- H2_Sorex CATLGVCHACGVAGHAERSASGWQPAKDSPPGEVLCEPPSLILSLQISGAPG-SPQTP-- H2_Monodelphis ----------------------------------------------NSGISS-SLGVP-- Tetraodon GDAMEHLPASNSGGPEEGGRGRQRAQKKPRRAENCEQIGADKLWQPKGGQRGVCPALAGG Takifugu GDAMEHLPASNSGAPENGDRGRQREQKKHRRAENCEDISTDKLWQMKGGQRGVCPALAAG Gasterostreus VDALEHLPARNPARPENGNRGRQRDPKRQQQQQHSGDVNTDKLWQKKGGQRGVCASFAAG Oryzias RDALEHLPVSYHDGPQSADRGRQREQK--QRAENHGNINTGNLWQVKGGQREVCPASADG Danio ---MELIKEET--APEDDSRGRQRDCR-------TSVVSSK---QVQRNQLEICPGLVSG Xenopus_laevis -----------------------------------------------MSEVGICKSLAGG Xenopus_tropicalis -----------------------------------------------MSELGICKSLAGG Callorhinchus ------------------------------------------------------------ Petromyzon -----------QKLSSPRAIVFIYSKVAAHQHEFYTAHDEQMAAVVSGAVPGTTDGPEEG Strongylocentrotus ------------------------------------------------------------ Ixodes ARVCAWCRDRCSGVSICSILSAFISHVRSCPTTSPLDWDTFTVSWDRVMGEVEVLNPSLA Trichinella ------------------------------------------------------------ D_sechellia -------------------------------------------------------CHCSV D_simulans --------------------------------------------------------HCSV D_erecta ------------------------------------------------------------ D_yakuba ------------------------------------------------------------ D_melanogaster ------------------------------------------------------------ D_ananassae ---------------------------------------------------------LAS D_persimilis ------------------------------------------------------------ D_pseudoobscura ------------------------------------------------------------ D_willistoni ------------------------------------------------------------ D_grimshawi ---------------------------------------------ATMATILLVDIDSIS D_virilis ------------------------------------------------------------ D_mojavensis ------------------------------------------------------------ Bombyx --------------------------------------------LTEKKVLLINYCFLMD Phlebotomus -------------------------------------------TVGPDSRDQVGASVLVS Anopheles ------------MSIENSMETAESMAFTRQCDEVDALPSQTAQSSGSCEPNVVGSSSSAA Aedes ----------------------------RRFSAVHER----SKPATAVESEMIGTAAAAL Culex ------------------------------------------MSAKNIENTSENRNFLAS Nasonia_vitripennis AAALRHASFGFFSPMQLRWLQQVGNLEIYSRRSFSNMRRFSIVRISLSELFDRGSVLLYH Nasonia_girault ------------------------------------------------------------ Apis CITANRRILVNIINMENHDVKTVMEKVSDGIDKVHDVKGVQAEPTPAASSLSLPVSEQVS Acyrthosiphon ------------------------------------------------------------ Tribolium RISLLCAPVGKQTNCATRKWRFLSSRVHLVVRSRRECFQTTALFEPFDGLIAPKRSQTVK Pediculus -------------------------------IIMSASEKIETTDVAIDNKLTIRETDDVN Brugia --------------------------MTATVVDQPDKQQNQQQDQEHTSKQHLSEQLQPE Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Aplysia ------------------------------------------------------------ Reniera -------------------------------------------RVLPRGVMLIVRPFPLS Trichoplax -------------------------------------------QSKMEENNQSDKAPQHG Lottia PGGEE--MKAEEKNISFGGENTSDVSVSPSDEDRKNGVNGAEHY---------------- Crassostrea SDSAS--VLRE-NGSPRECQQRKDTRAEPLGIENNNEVQEGSES---------------- Saccoglossus MPSLERRISGEFSKMEADDQRIESSECSPDETERSRTRRGGATN---------------- Ciona_intestinalis MATDVMRMDPAATDADCETSGTETHFAGNHRPVSSDP----------------------- Ciona_savignyi MAADVMRMDPTAIDADGETSGTETHFAGKRGSGSSET----------------------- Hydra -NTLENTPGEFKEQQNNDGAFLDGGLGTNENIYFVNAKRKDESR---------------- Nematostella GNEGDDERDGDERTSEHSGTEMPEKNYTSDQVTANHDKKEDSSD---------------- Capitella MAAIGGSTDGVSMAAE-ESEGPAQEVRDLEGPSQNGESCSSD------------------ Branchiostoma MADLEHSVSPEAEGMDGDDERTETELAEHDSPDSKRECHRNDGGDH-------------- Taeniopygia ------------------------------------------------------------ Gallus EAA---EAATAAEGAGDHEARPSEG---------GAAQPGLR------------------ Anolis QGT---APRRGSGAAGGSRERPHKQQDGREDACLGAEQGSFSRRGR-----------VRW H1_Bos GG----SPGHGGEGSLEPQPSPLKTQVCPESSCPEAGEKGQNGDDL----SAGGAPP--- H1_Sus GG----RPGQEGEGSQEPQLPPLQTQVSPESSCPEAGEKGQNGDDL----SAGGAPPPAA H1_Pan GG----RPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDS----SAGGDFPPPA H1_Homo GG----RPGPEGEGSLESQPPPLQTQACPESSCLREGEKGQNGDDS----SAGGDFPPPA H1_Pongo GG----RPGPEGEGSLESQPPLLQTQACPESSCLREGEKGQNGDDS----SAGGDFPPPA H1_Macaca GG----RPGPEGEGSLESQPPPLQPQACPESSCLIKGEKGQNGDDL----SAGGDFPPPA H1_Canis GG----RPGQEGEGSLGPQPPPLQTPVRPEPSCPEAGKKGQNGDDL----SAGGASPPAA H1_Felis ------------------------------------------------------------ H1_Equus DG----RPGLEGEGSLEPQPPPLQTQMCPESGCLEAGEKSHNGDDL----SAGGAPPPVA H1_Erinaceus ------------------------------------------------------------ H1_Microcebus GG----PPGLEGEGSLEPHPPPLQTQARSEPSCLEAGEMGQNGDDL----SADGDSPPAA H1_Otolemur GG----LPVPEGEGSLEPQPPPLQTQAYSQPTCLEAGEKGQNGDDL----STGDASPPAA H1_Myotis GG----RPGPEGEGSLDPQPSPLPTQVCPEPRCLEADEKGQNGDDS----SAGGPAPPPA H1_Rattus GS----RPGQEGDGGLKHQLPPLQTNACPELSCLEKGEKGQNGEDL----STGGASPSAE H1_Mus GS----RPGQEGEGGLKHQLPPLQTNACPELSSLEKGEKGQNGEDL----STGGASPSAE H1_Ochotona DG----RPGPAGEGS----PEPPQTQAGADP-----GDRGRNGAGL----ATGGAPSPAA H1_Oryctolagus GG----PPGPEGEGS----PQP---QACLEP-----GEKSQNGGDL----SAAGEPRAEA H1_Monodelphis DEI---LGKEEGGGNPAPAPPPRPTLACLDPGCPEGGEKGQNHDNLTAVGTAAAAAQPLG H1_Sorex ------------------------------------------------------------ H1_Cavia --------PPGGMGSPAPLQDPGD-------------------------GDGGGAAGPGG Ornithorhynchus ISD---VRDNQRSRVGHSETVQGQNGACWSPGLTYGKPHGDSGGTS----SPRTLLDPND H2_Bos -------PEPHDPGGSQPLTPRMESHSEEEDRPGAGGGLGWNGRSP-------------- H2_Canis -------PEPHDPGSSLPLTPRIESHSEEEDSPGAGRGLGWNSRGS-------------- H2_Equus -------PEPHDPGGSLPLTPQMESRLEEEDPPGTGGGLGWKTRGP-------------- H2_Erinaceus -------PEPHDPGDSLPLTPSMKNRSEEEDP--AGGAPGWDSKDP-------------- H2_Homo -------PERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSP-------------- H2_Pan -------PERHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSP-------------- H2_Pongo -------PEPHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWNSRSP-------------- H2_Macaca -------PGPHDSGGSLPLTPRMESHSEDEDLAGAVGGLGWYSRSP-------------- H2_Microcebus -------LEPLDSGGSLPLTPRMESHSEDEDLAGAGSGLGWNSRGP-------------- H2_Dasypus -------PEPHDPGISLPLTPRMENHSEDEDPARAGGGLGWNGRRS-------------- H2_Myotis -------PEPHDPAGSLPLTPRMESHSEEEDPSGAGGGLGCNSRGA-------------- H2_Rattus -------HEPHDFGGSLLLQPGREIQSEDEGTAPAGDGSSCNIRGS-------------- H2_Mus -------HEPHDFGGSQLLPSGQEIQSEDEGTVPAGDGSSCNIRGS-------------- H2_Felis -------PEPHDPGSSLPLTPRIESHSEEEDPTGAGSGLGWNNRAS-------------- H2_Ochotona ------PET-CDPGGSLPLTPQMESQLE-EGLGGAHNGLGWKSRDP-------------- H2_Oryctolagus LALQRAPQMPEDSGSCLPMTPRMESHLD-EDLAGAGSDLGWKSRGP-------------- H2_Spermophilus -------XXXXXXXXXXXXXXXXXXXXXXXXLAQAAGGLSWNCGGP-------------- H2_Tupaia ------------------------------------------------------------ H2_Loxodonta -------PVSHDPDRSLPLIPRMDSRPEDEDPAGAAG--GWNNRSP-------------- H2_Otolemur -------PQPHDSGDSLPLPPQMESHSEDEDLAGAEGGLGWNGRGP-------------- H2_Echinops -------SEPQDPGSSLPPTPRMESYSEDEDLTAAGGGLGWPSRSP-------------- H2_Sorex -------PESCDPGDSLPQTPQLDSHSEEDDGTGAGGAPGRDCRPS-------------- H2_Monodelphis -------SEPSDPGSCQPLTPGMDSPLEWKEPASNNNDSSGQNGTS-------------- Tetraodon KE----LLKCPVAARPHAKAE----ADGSHESNGKNGGERPLDGTL-------------- Takifugu NE----LLKCPIAARPHANAD----AEGSHESNGKNGGDGQLDGTL-------------- Gasterostreus NV----LPKCPNAAQPLQKPDG---LAAIHDPREKNGEDGPPEGTL-------------- Oryzias SE----LSKYPNATPFQRAPDGLPISANSHNPLRKNGQDRALQETL-------------- Danio DV----HPMCRDRSDPEPRTG---------DAASDDG--FPADKTS-------------- Xenopus_laevis GS----LLAPKEGGGWH--HPVEREEHPVGDANTVS----EGHDKE-------------- Xenopus_tropicalis GS----LLASKEGSGWQPVEEVEREEHPVRDPNPVSCREQKDPDKE-------------- Callorhinchus -----------------LVGVS-------------------------------------- Petromyzon SAR---RCGSGRAGAASPVGAAARDERGVGDVAAPTPRSHVQTQQQ-------------- Strongylocentrotus --------MAVESVQHIPQSRTHHGQQVLRNMQDANDQDGNGN----------------- Ixodes VVGGAPSTGEEQTTGSATAAGSAPRSVAAPPSEGSANCVGDRDQ---------------- Trichinella ----------------------------------SSNVVEQPAG---------------- D_sechellia QSCIFEYFGGSNLNLVVLLFPECGSQQRPLDGGGGGGG---------------------- D_simulans QSCIFEYFGGSNLNLFVLLFPESGSQQRPLDGGGGGGGSGGGGGG--------------- D_erecta ----------FNLNLVVFLLSESGSQQRPLDGGGGGGGSG-------------------- D_yakuba --------------MAEAVKNESGSQQRPLDGGGGGGGGS-------------------- D_melanogaster ---MAEAVKNGKNRHSGSAEKESGSQQRPLDSGGGGGASGGGGVA--------------- D_ananassae IAGFWRPNLKLWRLYQLSSFSDSTSQQRPLDGGGGGGGSGAG--S--------------- D_persimilis -----------VTVFDSNFLSESKSQ-RPLDGGGGGGGSGSGGPA--------------- D_pseudoobscura --------------MAEAVKTESKSQ-RPLDGGGGGGGSGSGGPA--------------- D_willistoni -----------IALYCLFVVSESSTQ-RPLDGGGGRHIS--------------------- D_grimshawi LLRCCCFPTHRVVFCDKFSAVMSNIRMQQIKCDCFVAESA-------------------- D_virilis ------------IKCNKYALFY-------------IVESA-------------------- D_mojavensis ------------FRFIVFK----------------ESSQG-------------------- Bombyx ADN-------LIIEDGEPTQSPVVGAPSIVEKQKPAS----------------------- Phlebotomus PE---------VSGNAEGVAAVAEGASGGGNQASGGS----------------------- Anopheles TVGAMVAPAATANDGGASVAAGEDGGRRPLDDDGRRSGGLVSRQDSNE------------ Aedes HV----APERTNNTSGETRTNTAPTATMSVDENDSASGNFAASS---------------- Culex QN----DVEPAQSATAAVTAAETTGALQAVPERTTNTSASAPPAT--------------- Nasonia_vitripennis RSTKTNVP---LLFDFQRLKPFIRTCTKFESGSGSGDQDGMISME--------------- Nasonia_girault -STKTNVP---LLFDFQRLKPFIRTCTKFESGSGSGDQDGMISME--------------- Apis LSTGENINKNNYINKKTCSKLLIKNSGKFESGSGSGDQEGGQ-HE--------------- Acyrthosiphon -------------------------------GPGTLDH---------------------- Tribolium MSEKSSEN-GPENPDGKTPATLPQGDVVQQKDARAPTRNEPKPKS--------------- Pediculus SEVVPSVDSDRNSSDWNLPASLTKFRENNHRRKRPRRKSKKGKYP--------------- Brugia HDIIIASMEGTDDEVAVAVLRDISTDESYQTTVENDPKNEQNYSG--------------- Ascaris ------------------------------------------------------------ Ancyclostoma --GVRREKGDHVFTATRVGTRSEARIEVYSAMASKELPSVARPD---------------- Haemonchus -------SFDKALCEN-----------SHSAMTLSERPTVVPHTS--------------- C_elegans -------------------------------MADYYGLFTSD------------------ C_remanei -------------------------------MADYYGLFASE------------------ C_brenneri -------------------------------MADYYGLLASET----------------- C_briggsae -------------------------------MAAESSSDNFELS---------------- C_japonica -------------------------------MAEMPAR---------------------- Aplysia ----------------------VRNPRARRGGACSHG----------------------- Reniera TSSSYCEPERTLMERAKSCSMSDEEDGRIQGPEQVAREKEEGPPLK-------------- Trichoplax VKRPMTKPSHRKNRRKNREGKKLKYASCVIKKIPIDGVTNQQNNNS-------------- Lottia ----------------------------SDQSGIPRK-----RKRRRIKGGGRHHKKWKP Crassostrea ----------------------------ENQCDSAEK-----KKRRRRLKGGKHHRKWKP Saccoglossus ----------------------------NNNHRTETNGNFVPGKKKHRRGKNKTKRRWKP Ciona_intestinalis ---------------------------ATDIADVGNAKK-HHHRRKPSKK----RRKWKP Ciona_savignyi ---------------------------MSESVDVVSAKKNHHHRRKPSKK----KRKWKP Hydra --------------------------LLTENEEKNGFAKRRHRRGSRKNKPRKPRQRYKP Nematostella --------------------------RFDKSGVKPMPISKKHRRGSRRCR----KKKYKP Capitella ----------------------------KEKGDDSSKWKRNRRKGKGG----KHRRGYKP Branchiostoma -------------------------PLEEHLNDRRRKHHRRGHRGSGAEGRRRFRRKWKP Taeniopygia ----------------------------------KLALWWIPKK---------KRR-WKP Gallus --------------------------PRYR-AAVGRAQEWPAKKKHRRRPSKNKRR-WNP Anolis RWLRTVAQLRVDRFIAGFCPCREYFGPRYRPQAAGEEERQLGKKKHRRRPSKKKRH-WKP H1_Bos ------------------------------------QQRQVGKKKHRRRPSKKKRL-WKP H1_Sus GGEQRP------------EANKLGASAAGGEEAWGQQQRQLGKKKHRRRPSKKKRL-WKP H1_Pan EVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Homo EVEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Pongo EMEPTPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Macaca EGEPKPEAELLAQPCHDSEASKLGAPAAGGEEEWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Canis GGEPKPEAEPLAQPCLDSEANKLGAPAAGGEEAWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Felis ---PRPEAEPLAQPCHDSEANKLGAPAAGGEEAWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Equus GGEPRPGAEPLAQPCPDSEANKLGAPAAGGEEAWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Erinaceus -----------------------------------GQQRQLGKKKHRRRPSKKKRH-WKP H1_Microcebus GGEPRPEAEPIAQPRHDSEANKLGAPAAGGEEACGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Otolemur GGEPRPEAELNAQPCHDSEANKLGAPAAGDEEAWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Myotis GGEQRPETEPLTQPCHDSEANKLGAPAAGGEESWKQQQRQLGKKKHRRRPSKKKRH-WKP H1_Rattus G---EPMSESLVQPGHDSEATKLEAPVAGVEEPWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Mus G---EPMSESLVQPGHDSEATKQEAPAAGGEEPWGQQQRQLGKKKHRRRPSKKKRH-WKP H1_Ochotona GADP---------PGQDSEANKLEAPAAGGEAAWGHQQRHLGKKKHRRRPSKKKRH-WKP H1_Oryctolagus --------------CQDSEPNKLEAPAAGAKEAWGQQQRHLGKKKHRRRPSKKKRH-WKP H1_Monodelphis EGHRPGTQPPQSCQGYGGDKFAVPVGQEEEAWRQQQQQRQLGKKKHRRRPSKKKRH-WKP H1_Sorex ----------------------------------GQQLRQLGKKKHRRRPSQKKRH-WKP H1_Cavia DGE-PSPAPPGP-------------DAEAPRTAWGPQPRQLGKKKHRRRPSKKKRH-WKP Ornithorhynchus PWDVPP-------PTPGMGASPEAPASPLEGETPAPRPKAPGRRKHRRRPSKQKRP-RRP H2_Bos ---------------------------RTQSLGACSAEAMLARKKHRRRPSKRKRH-WRP H2_Canis ---------------------------RTQSPGGSSVEAVLGRKKHRRRPSKRKRH-WRP H2_Equus ---------------------------WTRSPGSCSGEAVLGRKRHRRRPSKRRRH-WRP H2_Erinaceus ---------------------------RPQNLESCSVEAVLGRKKHRRRPSKRKRH-WRP H2_Homo ---------------------------RTQSPGGCSAEAVLARKKHRRRPSKRKRH-WRP H2_Pan ---------------------------RTQSPGGCSAEAVLARKKHRRRPSKRKRH-WRP H2_Pongo ---------------------------RTQSPGGCSAEAVLARKKHRRRPSKRKRH-WRP H2_Macaca ---------------------------RTQNPGGCSAEAVLARKKHRRRPSKRKRH-WRP H2_Microcebus ---------------------------QTQSPGACSAEAVLGRKKHRRRPSKRKRH-WRP H2_Dasypus ---------------------------RPQSPGGCSTKAVLGRKKHRRLPSKRKRH-WRP H2_Myotis ---------------------------RTQNPRGCSVEAVLGRKKHRRRPSKRKRH-WRP H2_Rattus ---------------------------RTQSPGGCSVEAVLARKKHRRRPSKRKRH-WRP H2_Mus ---------------------------RTQSPGGCSVEAVLARKKHRRRPSKRKRH-WRP H2_Felis ---------------------------RTQSPGGSSVEAVLGRKKHRRRPSKRKRH-WRP H2_Ochotona ---------------------------QDQGAEGYSVEPVLIRKKHRRRPSKRKRH-WRP H2_Oryctolagus ---------------------------QTQSSEGCSVEAVLGRKKHRRRPSKRKRH-WRP H2_Spermophilus ---------------------------QTQSPGGCSVEAVLGRKKHRRRPSKRKRH-WRP H2_Tupaia ----------------------------------XXXXXXXXXXXXXXXXXXXXXX-XXX H2_Loxodonta ---------------------------QTQSPAGCSAEAVFARKKHRRLPSKHKRH-WRP H2_Otolemur ---------------------------QTQSPGACSAEAVLGRKKHRRRPSKRKRH-WRP H2_Echinops ---------------------------RAQSPGACSAEAVLGRKKHRRRPSKRRRH-WRP H2_Sorex ---------------------------RTQSPEGSSVEAVLGRKKHRRRPTKRKRH-WRP H2_Monodelphis ---------------------------QFESP-GSGPTEALGRRKHRRRSSKRKRHGWRP Tetraodon ------------------TRVREEGALVDSDTGLDA---RLGRRKHRRRPSKKKRN-WKP Takifugu ------------------NQVREESALIDSDTGLDA---RLGRRKHRRRPSKKKRN-WKP Gasterostreus ------------------NPAPED-GHVDSDTGFDA---RLGKKRHRRRASKKKRN-WKP Oryzias ------------------NQVQVASLLIDSDAGFDA---RLGKKRHRRRTSKKKRN-WKP Danio ------------------SKRDSECAAVNTDGVSDG---RQGKKKHRRRPSKKKRR-WKP Xenopus_laevis ------------------SAYQNPGQLVKAEAQ-EDDWKELGKKRHRRLRSKNKRR-WKP Xenopus_tropicalis ------------------GGCQKPGQLAKAKPQQEGDWKELGKKRHRRLPSKNKRK-WKP Callorhinchus ---------------------------------------------------------LEP Petromyzon ----------------------------QQQQQPQQQPPTASRRRHRRRPSKKKQRRWRP Strongylocentrotus -----------------------------------------DKSRKRRRPRRKNRK-WKP Ixodes --------------------------LIAENPDETRARSGSTGKKKKNRRGKSKKRKWKP Trichinella --------------------------VMISSLRRQRR------PKRKKRTRRQVRRPWKP D_sechellia ------------------------------------GGCGAGMPKRKHRRGK-KSKMQPK D_simulans ------------------------------------GGCGAGMPKRKHRRGK-KSKMQPK D_erecta ------------------------------------GGGGAGMPKRKHRRGK-KSKMLPK D_yakuba ------------------------------------GGGGAGMPKRKHRRGK-KSKMLPK D_melanogaster ------------------------------------VGGGSGMPKRKHRRGK-KSKMQPK D_ananassae ------------------------------------GGGGGGIPKRKHRRGK-KSKMLPK D_persimilis ------------------------------------IGNHNSMPKRKHRRGK-KSKMVPK D_pseudoobscura ------------------------------------IGNHNSMPKRKHRRGK-KSKMVPK D_willistoni -----------------------------------------AMPKRKHRRGK-KSKMVPK D_grimshawi --------------------------------------QSVASQRRKHRRGK-KSKLLPK D_virilis --------------------------------------QSGASQRRKHRRGK-KSKMLPK D_mojavensis --------------------------------------VPGATQRRKHRRGK-KSKMLPK Bombyx ---------------------------------------VDGNVKKKRRRANTKRKVMTP Phlebotomus ---------------------------------------ERPKGKRKCRRGRAKAKRNNT Anopheles ---LSEANRDGKGHPGVGSNQGNGTGVPMATAATMSNRTGEGRCRRKNRRRKSNRGK-SS Aedes ----TAGIDDGLAAMSPGSGRGGGRRTTITEQG--SDGSDKNNSKRKTRRGKTKRGKRSS Culex ----TTKMDEAAGIARSSSSGGGGPNE---------KRRSNDGAKRKTRRGKAKRGKRSS Nasonia_vitripennis ------------------------------------DGVDVAAKKRKTRRGKPKHRKLKP Nasonia_girault ------------------------------------DGVDVAAKKRKTRRGKPKHRKLKP Apis ------------------------------------DGIDIAAKKRKTRRGKPKHRKLKP Acyrthosiphon -------------------------------------------RNRRTRRGKRKSRKQTP Tribolium ------------------------------------PECEIPTKKRKTRRGKSKRR--YP Pediculus ------------------------------------YSKTSWQQRRELASSERAQRIRQQ Brugia ----------------------------RIPDHGVLSASSSHAKTKKSRRRRGGKGRWKP Ascaris ------------------------------------------------------------ Ancyclostoma ----------------------------DHERSISDGDVELEKKRRKTRRR-ANKNRFKP Haemonchus ----------------------------DQERSVSDGDLETEKKRRKTRRRRANKSRFKP C_elegans ------------------------------TRSVSDGES-DGERRLRRSRRKRGGGRFRP C_remanei ------------------------------ARSVSDGES-DGERRLRRSRRKRGGGRYRP C_brenneri ------------------------------ARSLSDGES-DSERRLRRSRRKRGAVRARP C_briggsae ------------------------------ARSVSDGES-DGERRLRRSRRKRGG-RYRP C_japonica ------------------------------SMSASDGESSDAERRLRRSRRKRGGQRVRP Aplysia -----------------------------------------SRRHKGGSRHKKAFQPYPP Reniera ----------------------------------PSTNNKKHRRGKKRSGGPGGRPKWKP Trichoplax ---------------------------------KDEIGGWKKTRRGKKKRGKNNKKKFSN Lottia YDKLTWPEKKALEDKETI-------------RATQKREE--------------------- Crassostrea YEKLSWNERRELEERETQ-------------RATQKREE--------------------- Saccoglossus YTEMTWKEKKNLEDREAK-------------RAEEKRK---------------------- Ciona_intestinalis YSKMTWEEKREAEEREQV-------------RADRMRG---------------------- Ciona_savignyi YSKMTWEEKREAEEREQL-------------RADRIRC---------------------- Hydra FNKLTWDEKRQLDERDTV-------------KALRRREE--------------------- Nematostella YTKMTWDEKKARLELDAK-------------KATKMREQ--------------------- Capitella YCKMTWDEKKTQEERETK-------------RAFKKRE---------------------- Branchiostoma FVKLSWEERKDLEERERK-------------RAMRVRE---------------------- Taeniopygia YSKLSWEEKQQFDERQSL-------------RASRLRA---------------------- Gallus YSKLSWEEKQQFDERQSL-------------RASRLRA---------------------- Anolis YYKLTWEEKKKFDEKQSQ-------------RASRLRA---------------------- H1_Bos YYTLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Sus YYTLTWEEKKKFDEKESL-------------RASRIRA---------------------- H1_Pan YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Homo YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Pongo YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Macaca YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Canis YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Felis YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Equus YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Erinaceus YYKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Microcebus YIKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Otolemur YIKLTWEEKKKFDEKQSL-------------RASRIRA---------------------- H1_Myotis YYKLTWEEKRKFDEKQSL-------------RASRVRA---------------------- H1_Rattus YYKLTWEEKKKFDEKQSL-------------RASRVRA---------------------- H1_Mus YYKLTWEEKKKFDEKQSL-------------RASRVRA---------------------- H1_Ochotona YYKLTWEEK--------------------------------------------------- H1_Oryctolagus YYKLTWEEKKKFDEKQSL-------------RASRLRA---------------------- H1_Monodelphis YYKLTWEEKKKFDEKQSQ-------------RASRVRA---------------------- H1_Sorex YYKLTWGG----EEKSST-------------KRQ-------------------------- H1_Cavia YYKLSWEEKRKFDERQSL-------------RASRVRA---------------------- Ornithorhynchus YLQLSWAEKQQRDERQSQ-------------RASRLRA---------------------- H2_Bos YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Canis YLELSWAEKQQRDERQSQ-------------RASRIRE---------------------- H2_Equus YLELSWAEKRQQDERQGQ-------------RASRVRE---------------------- H2_Erinaceus YLELSWAEKQERDERQSQ-------------RASRVRE---------------------- H2_Homo YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Pan YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Pongo YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Macaca YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Microcebus YLELSWAEKQQRDERQSQ-------------RASRFRE---------------------- H2_Dasypus YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Myotis YLELSWDEKQQRDEKQGQ-------------RASRLRE---------------------- H2_Rattus YLELSWAEKQQRDERQSQ-------------RASRVRQ---------------------- H2_Mus YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Felis YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Ochotona YLELSWDEKQQRDEKQSQ-------------RASRVRE---------------------- H2_Oryctolagus YLELSWAEKQQRDEKQSQ-------------RASRVRE---------------------- H2_Spermophilus YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Tupaia XXXXXXXXXXXXXXXXXX-------------XXXXXXX---------------------- H2_Loxodonta YLELSWAEKQRRDERQSQ-------------RAFQVRE---------------------- H2_Otolemur YLELSWAEKQQRDERQSQ-------------RASRVRE---------------------- H2_Echinops YLELSWAEKQQRDERQSQ-------------RASQVRE---------------------- H2_Sorex YLELSWAEKQQRDEWQGQ-------------RASRVRE---------------------- H2_Monodelphis YLELSWAEKQQRDEQQSQ-------------RASRVRE---------------------- Tetraodon YFKLSWEERRALEEKETA-------------RASRLRE---------------------- Takifugu YFKLSWEERRALEEKETA-------------RASRLRE---------------------- Gasterostreus YYKLNWDERKALEEKETA-------------RASRLRE---------------------- Oryzias YNKLSWEEKKALEERETL-------------RASRMRE---------------------- Danio YFKLTWEEKKELDERETA-------------RASRVRA---------------------- Xenopus_laevis YDKLTWEEKKELEERQSQ-------------RASRIRA---------------------- Xenopus_tropicalis YCKLTWEEKKNLEERASQ-------------RASRIRA---------------------- Callorhinchus YFKLTWEEKKELDERESV-------------RAAKTRA---------------------- Petromyzon YLTLSWEEKKAMEERESE-------------RAARMRA---------------------- Strongylocentrotus YTQLSWEERQQRDEEESR-------------RASLKRA---------------------- Ixodes YYKLSWEERRELEERESR-------------RANRLRQ---------------------- Trichinella YFKLSLEERQRLELREER-------------RAERIRA---------------------- D_sechellia K-TKNHYPQWKLDMTTG--------GGTTLEGNQRQNS--------------------RT D_simulans K-TKNHYPQWKLDMTTG--------AGATLEGNQRQNS--------------------RT D_erecta K-TKNHYPQWKLDMPTN--------AGATLEGNQRQNS--------------------RT D_yakuba K-TKNHYPQWKLDMPTG--------AGATLEGNQRQNS--------------------RT D_melanogaster K-TKNHYPQWKLDMSTG--------AGATLEGNQRQNS--------------------RT D_ananassae K-TKNQYPQWKLDMPAKG------AGGGHVEGNPRQSSS-------------------RT D_persimilis K-TKNQCPQWKLDMASG-------------QGS--TATT-------------------RT D_pseudoobscura K-TKNQYPQWKLDMASG-------------QGS--TATT-------------------RT D_willistoni QNNKNHGPSWKLDMQPGSSAVAGGGAGSGGEASKRHNA--------------------RA D_grimshawi K-TKNQYPPWKMDMLPS-------APGGNGAPSAGSSVS-------------------RS D_virilis K-TKNQYPPWKMDLVTT-------STG-NGATSSGSSSA-------------------RT D_mojavensis K-TKNQYPPWKMDMGAV-------ATM-NSANASCSSGA-------------------RT Bombyx FVKAPWRDRRRNEKP--------------KRNNRFRKI---------------------- Phlebotomus HVKP-----YAWKLP--------------VATRRSAAS---------------------- Anopheles SNRPYSKTQWKFQCPPGG------QPGGGGGGGRPGGGAESNCNKRRHLYSVAASRRITP Aedes SARPYSKSQWKYHVP---------MLRSTAANKRRVKVSLGGLTTR----SAGIITTKDP Culex SSRPYTKSQWKFQNHVR--------IGAAVANKRRAES---------------------- Nasonia_vitripennis YSKQSLSYQQRLRNRAAV-----------------------------------------R Nasonia_girault YSKQSLSYQQRLRNRAAV-----------------------------------------R Apis YSKQQLSYQQQLRYRSRG-----------------------------------------R Acyrthosiphon YMKDGRLYRD-------------------------------------------------- Tribolium YQKNGRKSAK-------------------------------------------------- Pediculus MFHHG------------------------------------------------------- Brugia YRTSLKEK----IAQEEK-------------EERNAVEK-------------------RE Ascaris ------------------------------------------------------------ Ancyclostoma YHSLSPEEKMALDAAETA-------------RSERRTRE-------------------H- Haemonchus YHSLSPEEKIALDAAETA-------------RSERRIRE-------------------RX C_elegans YSPDYS------DDEKTK-------------PTKKNQK---------------------R C_remanei YSPGNS------DEETAK-------------DFDKKQKN-------------------KR C_brenneri YSPGNS------NSDDDE-------------QQLKQKK---------------------N C_briggsae YSP----------DAEQK-------------VDKKNRK---------------------- C_japonica YAISPE------NFAVEK-------------KPVNKRK---------------------- Aplysia QDEMKLKRRTLERKEKEN-------------AAAVVRRE-------------------EG Reniera YSKMSLEERKQVDEWEEK------------HVAIREAEIN-------------------- Trichoplax YQNLSCQEKAELEEMAAE-------------EATQLYN---------------------- Lottia AFAS-GHPVAPYNTTQFLMEDHIQSEASPDLLDVENGENINS------------------ Crassostrea AFAH-GHPVAPYNTTQFLMDDHGK--ADPNIGDGLLNRNNSR------------------ Saccoglossus ------HRLTPYNTTQFLMEDHKVNTPDFNMDGTYSRQTSMD------------------ Ciona_intestinalis EMIKRGRPVAPYNTTQFIMAEHDNYEADDDHYDNYNNKNQNVDSSENA----------DG Ciona_savignyi EMIKRGRPVAPYNTTQFIMAEHDTYEG-----DSLDQKDQ------------------GG Hydra LVLQKGRPIAPYNTTQFLMEEHNPGEENFQN----QNTTLHP------------------ Nematostella YMHEKGRPAAPYNTTQFLMDEHDQEEPDLG-------AHSHM------------------ Capitella KRFASGQPMAPYNTTQFLMDQHDSMDSTH------LEDPKEA------------------ Branchiostoma MMFAEGRTVAPYNTTQFLMEDHETQSXFHSPNLEVLQRQQSN------------------ Taeniopygia EMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTG---------------------------- Gallus EMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTG---------------------------- Anolis EMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTG---------------------------- H1_Bos EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Sus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Pan EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Homo EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Pongo EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Macaca EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Canis EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Felis EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Equus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Erinaceus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Microcebus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Otolemur EMFAKGQPVAPYNTTQFLMEDHDQEEPDLKTG---------------------------- H1_Myotis EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Rattus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Mus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Monodelphis EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H1_Sorex ---SPGEPSXXXXXXXXXXXXXXXXXXXXXX----------------------------- H1_Cavia EMFAKGQPVAPYNTTQFLMDDHDQEEPDLKTG---------------------------- Ornithorhynchus QMFAKGQPAAPYNTTQFLMDDHDQEEPDLKTG---------------------------- H2_Bos EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Canis EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-EV---------------------------- H2_Equus EMFAKGQPVAPYNTTQFLMNDRDPVEPNL-DV---------------------------- H2_Erinaceus EMFAKGQPVAPYNTTQFLMDDRNPEEPNL-DV---------------------------- H2_Homo EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Pan EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Pongo EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Macaca EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Microcebus KMFAKPXXXXXX---------XXXXXXXX-XX---------------------------- H2_Dasypus EMFAKGQPVAPYNTTQFLMNDRDPEEPDL-DV---------------------------- H2_Myotis EMFAKGQAVAPYNTTQFLMNDRNPEEPDL-DV---------------------------- H2_Rattus EMFAKGQPLAPYNTTQFLMNDRDLEEPNL-DV---------------------------- H2_Mus EMFAKGQPLAPYNTTQFLMNDRDLEEPNL-DV---------------------------- H2_Felis EMFAKGQPVAPYNTTQFLMNDRDPEEPNLGSA---------------------------- H2_Ochotona EMFAKGQPVAPYNTTQFLMNDRAPEEPDL-HV---------------------------- H2_Oryctolagus EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Spermophilus EMFAKGQPVAPYNTTQFLMNDRDPEEPNLEVP---------------------------- H2_Tupaia XXXXXXXXXXXXXXXXFLMNDRDPEEPNLYVP---------------------------- H2_Loxodonta EMFAKGQPVAPYNTTQFLMNDRDPEEPDL-DV---------------------------- H2_Otolemur EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Echinops EMFAKGQPVAPYNTTQFLMNDRDPEEPDL-DV---------------------------- H2_Sorex EMFAKGQPVAPYNTTQFLMNDRDPEEPNL-DV---------------------------- H2_Monodelphis EMFAKGQAVAPYNTTQFLMEDHDLEEPDL-EN---------------------------- Tetraodon QMFAKGLPVAPYNTTQFLMDEHDREEPDLNTE---------------------------- Takifugu QMFAKGLPVAPYNTTQFLMDEHDREEPDLNTE---------------------------- Gasterostreus EMFAKGLPVAPYNTTQFLMDEHDRVEPDLNTE---------------------------- Oryzias EMFAKGLPVAPYNTTQFLMDEHDREEPDLNTE---------------------------- Danio EMFAKGLPVAPYNTTQFLMEEHDREEPDLNTE---------------------------- Xenopus_laevis EMIAKGQPVAPYNTTQFLMEDHDQEEPDLCPP---------------------------- Xenopus_tropicalis EMIAKGQPVAPYNTTQFLMEDHDQEEPDLCPP---------------------------- Callorhinchus EMFAKGFTVAPYNTTQFLMDEHDREEPDLNPGFCPHAVAAAAAAA--------------- Petromyzon EMAAKGLAVAPYNTTQFLMDEHDREEPDLEP----------------------------- Strongylocentrotus N------RPTPYNTTQFLMEDHKVVTPDLSNMG--------------------------- Ixodes QMFAHGQPVAPYNTTQFLMEDHCVQEPD-------------------------------- Trichinella QRFAHGLPVAPYNTTQFLLDDREARESEPICVDEIVDTIRHEGAVNDH----------HG D_sechellia KLVRSRSLLVPYNTNRFLMEEHMSELH--------------------------------- D_simulans KLVRSRSLLVPYNTNRFLMEEHMSELH--------------------------------- D_erecta KLVRSRSLLVPYNTNRFLMEEHMSELH--------------------------------- D_yakuba KLVRSRSLLVPYNTNRFLMEEHMSELH--------------------------------- D_melanogaster KLVRSRSLLVPYNTNRFLMEEHMSELH--------------------------------- D_ananassae KLVRSRSLLVPYNTNRFLMEEHMSELP--------------------------------- D_persimilis KLLRSRSLLVPYNTNRFLMEEHMSEVP--------------------------------- D_pseudoobscura KLLRSRSLLVPYNTNRFLMEEHMSEVP--------------------------------- D_willistoni KLVRSRSLLVPYNTNRFLMEEHMSELR--------------------------------- D_grimshawi KLVRSRSLLVPYNTNRFLMEEHMSELP--------------------------------- D_virilis KLVRSRSLLVPYNTNRFLMEEHMSELP--------------------------------- D_mojavensis KLVRSRSLLVPYNTNRFLMEEHMSELP--------------------------------- Bombyx ---VLTKTHAPFNNNQFLMEIHKPEPENAFNILQTPSA---------------------- Phlebotomus ---HIRSSIVPYNTNKFLMEDHMQE-------MQTPKG---------------------- Anopheles FLKSDQPPLVPYNTNRFLMEDHMPQ-------VLTPSG---------------------- Aedes FILSDQPPLVPYNTNRFLMEDHMPH-------VLTPSG---------------------- Culex --LSDHPPLVPYNTNRFLMEDHMPQ-------VLTPS----------------------- Nasonia_vitripennis PTKTGRQPPAPYNTTQFLMEDHNDLPDLDEKIAGAATGTAGAAAAVAAMAAEVHNHFSKP Nasonia_girault PTKTGRQPPAPYNTTQFLMEDHNDLPDLDEKIAGAATGTAGAAAAVAAMAAEVHNHFSKP Apis LAKTGRQPPALYNTTQFLMDDHSDLPDLDQKLSEAAS-------------SELPATFQKP Acyrthosiphon ------KAVAPNNTNQFLMDDHNDGPDIDKKLLARYS----------------------- Tribolium ----VIKPEAPYNSNQFLLEDHGNIEELDENLKNADQ----------------------H Pediculus ------QPVAPYNTTQFLIEDHGDLQKIDAQLQVVQE--------------QNPGSSVVN Brugia RLFSRGKPMAPYNTTQFLVEDHEKRTMPPDVSD------------------------SLP Ascaris TLFCRVRLLS-------------------------------------------------- Ancyclostoma --MAHGKPMAPSNTTQFLLEDREARAEQGLE--------------------------VEL Haemonchus XXMANGKPMAPSNTTQFLLEDREARAEKGLEXXX-----------------------VEL C_elegans PDKQDRFGMAPPNSTQFLLEDREARADAEFE--------------------------NEQ C_remanei AEKPDRFGMAPPNSTQFLLDDREARADAEFE--------------------------NEQ C_brenneri AYRSDRYGMAPPNSTQFLLDDREARADAELE--------------------------AEQ C_briggsae ADKQDRYGMAPPNSTQFLLDDREARADAEYE--------------------------IEQ C_japonica --LRDRRGMAPPNSTQFLLDDREERANAEYE--------------------------NEQ Aplysia GQEFIRFPVAPFNSTQYLMDEHNVNSPVGLHKTPSSSK---------------------- Reniera --ARSKRPVAPFNSTQFLIDDRCEDQYRRPSRTLSFDSSSGVTG-------------AMG Trichoplax QRIQSGLPVTPFNTTQFIMDDYEKARARSVND---------------------------- Lottia --SLRDSFHSDADGSSDLEYG--------------------------------------- Crassostrea --ESTDGSGSTSDSSEEMNS---------------------------------------- Saccoglossus --SSDELCTSDG------------------------------------------------ Ciona_intestinalis GVSSTSGAHSMVNHVGSPA----------------------------------------- Ciona_savignyi SVFSTSGGHSVVNQTESPANTDDF------------------------------------ Hydra ---TADLSEDSCSSSSSDE----------------------------------------- Nematostella ---QSDGEDDTSNSTGRPR----------------------------------------- Capitella ---SFDSSDDFHDSNEDDT----------------------------------------- Branchiostoma ---DTSNSDDMPDSPEDDFG---------------------------------------- Taeniopygia --LYPRRAAAKSDDTSEED---------FLDDAADEDGGSDG------------------ Gallus --LYPRRSAAKSDDTSEED---------FLEEAAEEDGGSDG------------------ Anolis --LCPKKAAAKPEDTSEEE---------FVEE---EDGGSDG------------------ H1_Bos --LYPKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Sus --LYPKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Pan --LYSKRAAAKSDDTSDDD---------FMEEGGEEDGGSDG------------------ H1_Homo --LYSKRAAAKSDDTSDDD---------FMEEGGEEDGGSDG------------------ H1_Pongo --LYSKRAAAKSDDTSDDD---------FMEEGGEEDGGSDG------------------ H1_Macaca --LYSKRAAAKSDDTSDDD---------FMEEGGEEDGGSDG------------------ H1_Canis --LYPKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Felis --LYPKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Equus --LYPKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Erinaceus --LYPKRAATKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Microcebus --LYSKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Otolemur --LYSKRAAAKSDDTSDED---------FMEEAGEEDGGSDG------------------ H1_Myotis --FYPKRAAAKS-DTSDEE---------FMEEAGEEDGGSDG------------------ H1_Rattus --LYPKRAAAKSDDTSDED---------FVEEAGEEDGGSDG------------------ H1_Mus --LYPKRAAAKSDDTSDED---------FVEEAGEEDGGSDG------------------ H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus --LYPKRAAAKSDDTSDED---------FMDEAGEEDGGSDG------------------ H1_Monodelphis --LYTKRAAAKSDDTSDED---------FLEEAGEEDGGSDG------------------ H1_Sorex -------------------------------XXXXXXXGSDG------------------ H1_Cavia --LCPRRAAK--SDSSDED---------FLEEAGEEDGGSDG------------------ Ornithorhynchus --LYPKRAAAKSDDTSDED---------FVEEAGEEDGGSDG------------------ H2_Bos --PQGASHPGSSGESEAG----------------DSDGQ--------------------- H2_Canis --PHGASHPGSSGESEAG----------------EGDGQ--------------------- H2_Equus --PHGASHPGSSGDSEAG----------------DSDG---------------------- H2_Erinaceus --PHGASHPGSSGESEAE----------------DSDGQ--------------------- H2_Homo --PHGISHPGSSGESEAG----------------DSDGR--------------------- H2_Pan --PHGISHPGSSGESEAG----------------DSDGR--------------------- H2_Pongo --PHGISHPGSSGESEAG----------------DSDGR--------------------- H2_Macaca --PHGISHPGSSGESEAG----------------DSDGR--------------------- H2_Microcebus --XXXISHPGSSGESEAXX---------XXXXGRDSDGR--------------------- H2_Dasypus --PHGVSHPGSSGESEAG----------------DNDGP--------------------- H2_Myotis --PQGASHPGSSEESEAE----------------DSGRP--------------------- H2_Rattus --LHGPSHADSGGENEAG----------------DSDGL--------------------- H2_Mus --LHGPSHSGSGGENEAG----------------DSDGQ--------------------- H2_Felis --PWGLPARLQRGE----------------------RGR--------------------- H2_Ochotona --PASISHPDSSGESEAG----------------DSDGR--------------------- H2_Oryctolagus --PHGVSHPGSGGESEGG----------------DSDGR--------------------- H2_Spermophilus --PYGASHPGSSGDSEAG----------------DSDGQ--------------------- H2_Tupaia --P-GVSHPGSSGDSEAG----------------DSDGQ--------------------- H2_Loxodonta --PHRVSHPGSSGESEAG----------------DSDG---------------------- H2_Otolemur --PHSISHPGSSGESEAG----------------DSDGGAELKVSSSSGSSLRLMNAITQ H2_Echinops --PYGVSHPGSSGESEAG----------------DSDG---------------------- H2_Sorex --PHGASHPGSSGDSEAG----------------DSDG---------------------- H2_Monodelphis --HQGVPHQGSGWEEEDEE---------EGGGTGDLDGR--------------------- Tetraodon --TGARRPCGV----EDTVSEEDLFEPNPNEDEDDDDGSGGGG----------------- Takifugu --TGIRRPCGIGVRIEDTVSEEDLFDPNPNEDEDDDDGSGGG------------------ Gasterostreus --SGVRRPSGVGGRAEDTGSEEDLFD-NTNEEEEEDDGSGGGGG---------------- Oryzias --A--RRSLGVGGRPEETGSEEEVLD--NEQEDDDDDGSGGG------------------ Danio --LGGRKSGAIR--SEDTASEDENFE---AEEDDEEEG-GGG------------------ Xenopus_laevis --P--RKSSAALPLALNNSSYKGDSTDDDLEEEEDEAG---------------------- Xenopus_tropicalis --P--RKSSAALPLAIINSSYKG--STDDLEEEEDETG---------------------- Callorhinchus AAHHHKRGAGKADDSSGEDDELL-----LLEEAEEEESGSDG------------------ Petromyzon AGSDGGGGDNDGDEDSDEGD----------DGGEGDDELPSR------------------ Strongylocentrotus --AFDENHDVNLSSSDEVLE---------------------------------------- Ixodes --FESRNGHHRHREDSVNS--------------VDSSDEFYS------------------ Trichinella HTKHVPNHHHHHHSDHMVG--------------DEYSSDSVT------------------ D_sechellia -----------KDDSDDNCFGS-------------------------------------- D_simulans -----------KDDSDDNCFGS-------------------------------------- D_erecta -----------KDDSDDNCFGS-------------------------------------- D_yakuba -----------KDDSDDNCFGS-------------------------------------- D_melanogaster -----------KDDSDDNCFGS-------------------------------------- D_ananassae -----------KDDSDDNCFSS-------------------------------------- D_persimilis -----------KDDSDDNCFGS-------------------------------------- D_pseudoobscura -----------KDDSDDNCFGS-------------------------------------- D_willistoni -----------KDDSDDNCFGS-------------------------------------- D_grimshawi -----------KDDFDDNCFGN-------------------------------------- D_virilis -----------KDDFDDNCFGS-------------------------------------- D_mojavensis -----------RDDFEDNCFGS-------------------------------------- Bombyx ----RTRDSSFSVDSDDNYFYA-------------------------------------- Phlebotomus ----RQRDSSFSVDSDENYFCS-------------------------------------- Anopheles ----RTRDSSFSIDSEENYFYS-------------------------------------- Aedes ----RTRDSSFSIDSEENYFYS-------------------------------------- Culex ------------------------------------------------------------ Nasonia_vitripennis IAPSRTRDSSFSVDSDEDYFYS-------------------------------------- Nasonia_girault IAPSRTRDSSFSVDSDEDYFYS-------------------------------------- Apis SAPSRTRDSSFSVDSDEDYFYS-------------------------------------- Acyrthosiphon NENGRTRNSSYTSVESEGDQYS-------------------------------------- Tribolium STTSRTRDSSFSVDS-EGEFYS-------------------------------------- Pediculus NKPSRARDSSFSIDSDIDYFYS-------------------------------------- Brugia AMVAHQRQSTGVFSPARERCGTI------------------------------------- Ascaris ------------------------------------------------------------ Ancyclostoma AHEESERRRVRSISVSSEFMAAS------------------------------------- Haemonchus AYEASERKRVRSISVSSEFMAAS------------------------------------- C_elegans KFEAAERRRVRTMSGSYEHMRP--AYWCTIEPATTTADFGSDDN---------------- C_remanei RFEAAERRRVRTMSGSYDHMRP--AYWCTIEPATTTTYHDDDDR---------------- C_brenneri KFEAAERRRVRTMSGSYEHMRPS-AYWCTIEPAHTTTASTPSTTNEAAPGY--------- C_briggsae KFEASERRRVRTMSGSYDHMRP--AYWCTVEPATTTTVALEDHED--------------- C_japonica KFEAAERRRIRSLSGSFEQMRHAFSGATTIEPATTTTTIASTACGSGSG----------- Aplysia LELCSNSSPAPASVHSTPMHYS-------------------------------------- Reniera KWANSSSNIITPSPSPGASDGTNNKCFFFYPLSLGDDVHYDLS----------------- Trichoplax ---NSDDLLDEIQRMEDKS----------------------------------------- Lottia ---------------------------ADEDETFLAKEFSEAYDNIHAERLQTMSKEQLV Crassostrea -----------------------------EEEEFLEKEFAETYDNMHAERLQKMSKQELI Saccoglossus ------------------------------EVQFFEKDFSETYERLHEEALHSMIKTDLV Ciona_intestinalis -------------------VETDYTDSPHMAPEFISQDFSETYERVQEENLSIMSRNDLV Ciona_savignyi -------------------LETDYTDSPHMAPEFISQDFSEAYERVQEENLSIMSRNDLV Hydra ---------------------------------YFVKDFDEFYERVHIDTLNSYSKEDLI Nematostella ---------------------------------LQSQSMDDS----DLEDYNESPEDEIY Capitella ---------------------------------FLHKDFDEAYDNYHAERLHAMSKGELI Branchiostoma -----------------------------MEAGFFEKDFSETYEQFHAESLNNMSKTDLI Taeniopygia --------------------------MGGDGSEFLQRDFSETYERYHVESLQNMSKQELV Gallus --------------------------MGGDGSEFLQRDFSETYERYHVESLQNMSKQELV Anolis --------------------------MGGDGSEFLQKDFSETYERFHVESLQNMSKQELI H1_Bos --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Sus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Pan --------------------------MGGDGSEFLQRDFSETYERYHTESLQNMSKQELI H1_Homo --------------------------MGGDGSEFLQRDFSETYERYHTESLQNMSKQELI H1_Pongo --------------------------MGGDGSEFLQRDFSETYERYHTESLQNMSKQELI H1_Macaca --------------------------MGGDGSEFLQRDFSETYERYHTESLQNMSKQELI H1_Canis --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Felis --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Equus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Erinaceus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Microcebus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Otolemur --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Myotis --------------------------MGGDGSEFLQRDFSETYERFHAESLQNMSKQELI H1_Rattus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Mus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Monodelphis --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Sorex --------------------------MGGDGSEFLQRDFSETYERYHAESLQNMSKQELI H1_Cavia --------------------------MGGDGGEFLQRDFSETYERYHAESLQNMSKQELI Ornithorhynchus --------------------------MGGDGGEFLQRDFSETYQRFYFESLRSWGKEALI H2_Bos ---------------------------GRARGEFQQKDFSEAYERYHTESLQGRSKEELV H2_Canis ---------------------------GRAHGEFQQRDFSEAYERYHTESLQGRSKQELV H2_Equus ---------------------------GQVHGEFQQRDFSEAYERYHTERLQGLSKQELV H2_Erinaceus ---------------------------GQALGEFQQRDFSETYERYYTESLQDRSKPELV H2_Homo ---------------------------GRAHGEFQRKDFSETYERFHTESLQGRSKQELV H2_Pan ---------------------------GRAHGEFQRKDFSETYERFHTESLQGRSKQELV H2_Pongo ---------------------------GRAHGEFQRKDFSETYERFHTESLQGRSKQELV H2_Macaca ---------------------------GRAHGEFQRKDFSETYERFHTESLQGRSKQELV H2_Microcebus ---------------------------GRAQGEFQQRDFSETYERYHTESLQGRSKQELV H2_Dasypus ---------------------------GRAHGEFLQRDFFEAYERYHTESLQGRSKQELV H2_Myotis ---------------------------VRAPGEFQQRDFSETYERFHTESLQGRSKQELV H2_Rattus ---------------------------GRAHGEFQQRDFSEAYERYHTESLQGRSKQELV H2_Mus ---------------------------GRAHGEFQQRDFSEAYERYHTESLQGRSKQELV H2_Felis ---------------------------GKATGEAR-LTVSXXXXXXXXXXXXXXXXXXXX H2_Ochotona ---------------------------DQACGEFQQRDFSEAYERYHAESLQGRSKQELV H2_Oryctolagus ---------------------------GRAHGEFQQRDFSEAYERYHTESLQGRSKQELV H2_Spermophilus ---------------------------GQDHGEFQQRDFSEAYERYHTESLQGRSKQELV H2_Tupaia ---------------------------DRVHGEFQQRDFSEAYERYHTESLQDRSKQELV H2_Loxodonta --------------------------PGQAHGEFLQRDFSEAYERYRH------------ H2_Otolemur RACRAAASRSWXXXXXXXXXGRGQRRRGRAQGEFQQREFSEAYERYHTESLQGRSKQELV H2_Echinops --------------------------RDQAHGEFLQRDFSAAYEGYHTESLQGRSKQELV H2_Sorex --------------------------HGTAHGEFQQRDSRRXXXXXXXXXXX-------- H2_Monodelphis ---------------------------GKAQGEFLQRDFSETYEHYQVESLQGRSKQELV Tetraodon --------------------SDGIGRPGNAGGEFLQRDFSETYEMYHVESLQNMTKQELV Takifugu --------------------SDGIGRPGNAGGEFLQRDFSETYEMYHVESLQNMTKQELV Gasterostreus --------------------SDGIGRPGNAGGEFLQRDFSETYEMYHVESLQNMTKQELV Oryzias --------------------SDGIGRPGNAGGEFLQRDFSETYEMYHVETLQNMSKQELV Danio --------------------SDGMGRPGQAGGEFLQKDFSETYEKYHVEALQNMSKQELV Xenopus_laevis --------------------SDGMG--GYDGEDFLQKDFSETYERYHAESLQDMSKQDLI Xenopus_tropicalis --------------------SDGMG--VYDGEDFLQKDFSETYERYHAESLQDMSKQELI Callorhinchus --------------------------MGGSGSEFLQRDFCETYERYHAETLQNMSKQELI Petromyzon --------------------------LQGGRDGFLQRDFSETYERYHVESLSAMSKGELV Strongylocentrotus ----------------------------NENEEYLVRNFTAVYDEVQSERLQQMSKEQLV Ixodes --------------------------SPEDEDDFLQKQFSEAYDDVHAERLSSMSKAELV Trichinella --------------------------TSEGDLCMLEREFDYEYETAHAERLEEMSKEQLV D_sechellia --------------------------QTEDQVLFLSKEFSDVYERARLERLETMSKQELI D_simulans --------------------------QTEDQVLFLSKEFSDVYERARLERLETMSKQELI D_erecta --------------------------QTEDQVLFLSKEFSDVYERARLERLETMSKQELI D_yakuba --------------------------QTEDQVLFLSKEFSDVYERARLERLETMSKQELI D_melanogaster --------------------------QTEDQVLFLSKEFSDVYERARLERLETMSKQELI D_ananassae --------------------------QTEDQVLFLSKEFSNVYERARLERLETMSKQDLI D_persimilis --------------------------QTE--VLFLSKEFSNVYERVRIERLETMSKAELI D_pseudoobscura --------------------------QTE--VLFLSKEFSNVYERVRIERLETMSKAELI D_willistoni --------------------------QTE--VLFLSKEFSNVYERARLERLDTMSKQELI D_grimshawi --------------------------QTEDQELFLSKEFSNVYERARVERLETMSKQELI D_virilis --------------------------QTEDQELFLSKEFSNVYERARVERLETMNKQELI D_mojavensis --------------------------QTEDQELFLSKEFSNVYERARVERLETMSKQELI Bombyx --------------------------LPEDEEEYLTKEFSSVYEDAQCERLSNMTKNELI Phlebotomus --------------------------LPEDEEEFLTKEFSSVYENAKCERLDGLTKPQLI Anopheles --------------------------LPEDEEDFLTKEFSSVYERERFERLESLSHPDLV Aedes --------------------------LPEDEEEFLTKEFSSVYEDARSERLEGLSKSQLI Culex ----------------------------EDEEEFLTKEFSSVYEDARSERLEGLSKTQLI Nasonia_vitripennis --------------------------SPEDEEEFLTKEFSSAYEDLHAERLGALTKTELI Nasonia_girault --------------------------SPEDEEEFLTKEFSSAYEDLHAERLGALTKTELI Apis --------------------------SPEDEEEFLTKEFSTAYEDLHAERLSTLSKSELI Acyrthosiphon --------------------------SSSDDGTSIQKEFIDTYRLVQEEELAVLTKNELV Tribolium --------------------------SPDDEEQFLIKDFVDQYESVQAERLQSMSKDELI Pediculus --------------------------SPEDEEEFLTKEFSNAYEDLHVERLSSMSKSEII Brugia ----------GQSGSEMGGNTTDSASYSGAEDDEMERQFDADYDYVNMERISNMTKDDVA Ascaris -------------GSDPGGNTSESGSVSGEEGERLEREFDAEYDSVNLMRISGMSREEVS Ancyclostoma ------------------EGASSSGDS--ETDKEMDREFEAEFEEYTMDRLSRLTKDEMT Haemonchus ------------------EGASSSGDS--ETDKEMVREFEADFEEYTMDRISKLHKDGVX C_elegans --------------NDLDS---TSGES--EADREMEREFETDYLEVKRERIQSMTRSQLA C_remanei --------------HDVDSGSSSSGES--EADREMEREFETDYLEVKRERIQSMTKSQLA C_brenneri ----------VVEPEDVADNSSCSGSS--CSDREMEREFENEYLEVKRERIQSMTRSQLA C_briggsae --------------VESVSTSCCSDESEAAADREMEREFESDYQASKRERIQSMTKSQLA C_japonica --------------CGTDAEESVSGES--EADREMEREFETDYLEVKRERIQSMTRSQLA Aplysia --------------------------QGIMNLEKKDKEFVDIYTSVHAESLQSLPKEELV Reniera ---------------------------DEDQEAFLEADFNQVYLQLKLNRLEGMSKQDLI Trichoplax ----------------------------ENGNYSGEDEFTAHLEEIRFDKYDRMSKGELV Lottia KDYVELERKVETL------------------EKKLKDSNQNKR----------------- Crassostrea KDYIEMETKLDRL------------------QKRLE--RRNRR----------------- Saccoglossus KEFIRVENYVTEL------------------EESLKLEKQKR------------------ Ciona_intestinalis QEHINLERNLSYL------------------QDRLAEEKTITNSYSI------------- Ciona_savignyi QEHISLERNLSYL------------------Q--------VHSPYTV------------- Hydra KYVFELEARIEKF------------------ERENKNSDN-------------------- Nematostella EQQFFEKDFTEAY------------------EQVHAES---------------------- Capitella AEHLALESKIEDA------------------EKDLKSLKSGNNNSD-------------- Branchiostoma REYLEMEKCVERL------------------EAKLETASKEDNSSED------------- Taeniopygia KEYLELEKCLSRM------------------EEENNRLRM-------------------- Gallus KEYLELEKCLSRM------------------EDENNRLRM-------------------- Anolis QEYLELEKCLSRM------------------EEENNRLRM-------------------- H1_Bos KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Sus REYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Pan KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Homo KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Pongo KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Macaca KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Canis KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Felis KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Equus KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Erinaceus KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Microcebus KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Otolemur KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Myotis REYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Rattus KEYLELEKCLSRK------------------EDENNRLRL-------------------- H1_Mus KEYLELEKCLSRK------------------EDENNRLRL-------------------- H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Monodelphis KEYMELEKCLSRM------------------EDENNRLRL-------------------- H1_Sorex KEYLELEKCLSRM------------------EDENNRLRL-------------------- H1_Cavia REYLELEKCLSRM------------------EDENNRLRL-------------------- Ornithorhynchus REG--------LL------------------EDEP------------------------- H2_Bos RDYLDLERRLSQA------------------EEEMRRLRQ-------------------- H2_Canis RDYLDLERRLSQA------------------EEETRRLKQ-------------------- H2_Equus QDYLDLERRLSQA------------------EEETRRLQQ-------------------- H2_Erinaceus QRYLDLERRLSKA------------------EEETRRLQQ-------------------- H2_Homo RDYLELEKRLSQA------------------EEETRRLQQ-------------------- H2_Pan RDYLELEKRLSQA------------------EEETRRLQQ-------------------- H2_Pongo RDYLELEKRLSQA------------------EEETRRLQQ-------------------- H2_Macaca RDYLELEKRLSQA------------------EEETRRLQQ-------------------- H2_Microcebus RDYLELEKRLSQA------------------EDETRRLQR-------------------- H2_Dasypus QDYLDLEKRLSQA------------------EEETRRLQQ-------------------- H2_Myotis QDYLDLERRLSLA------------------EEETRKLQQ-------------------- H2_Rattus RDYLDLERRLSQA------------------EQETRRLQQ-------------------- H2_Mus RDYLDLERRLSQA------------------EQETRRLRQ-------------------- H2_Felis XXXXXLERRLSQA------------------EEETRRLQQ-------------------- H2_Ochotona RDYLDLERRLSQA------------------EEETRRLQR-------------------- H2_Oryctolagus RDYLDLERRLSQA------------------EEETRRLQQ-------------------- H2_Spermophilus RDYLDLERRLTQA------------------EEETRRLQQ-------------------- H2_Tupaia RDYLDLEKRLLQA------------------EEETRRLQQ-------------------- H2_Loxodonta ------------------------------------------------------------ H2_Otolemur TRLPGAGESARVA------------------GXXXXXXXX-------------------- H2_Echinops R----------------------------------------------------------- H2_Sorex ------------------------------------------------------------ H2_Monodelphis RDYLELEKRLSRA------------------EEETRRLQQ-------------------- Tetraodon QEYLELEKCMSRL------------------EEENNRLRR-------------------- Takifugu QEYLELEKCMSRL------------------EEENNRLRR-------------------- Gasterostreus QEYLELEKCMSRM------------------EEENNRLRR-------------------- Oryzias QEYLELEKCMSRL------------------EEENNRLRR-------------------- Danio REYLELEKCMSRL------------------EEENNWLRH-------------------- Xenopus_laevis KEYLELEKCLSRM------------------EEENNHLR--------------------- Xenopus_tropicalis REYMELEKCLSRM------------------EDENNRLR--------------------- Callorhinchus REYLELEKCLSRL------------------EDEKNRLRR-------------------- Petromyzon REYLELEKCLSRL------------------EEENLRLRECLGERGCWRGPAVALEAKPA Strongylocentrotus NEVLELSKKVSEL------------------EQILRPGSG-------------------- Ixodes QEYLLLEDRVEDL------------------EQKLRAARA-------------------- Trichinella QEYIHLEKELERY------------------QSESAQLRS-------------------- D_sechellia QECMQIEDRYSK-----------AQNISKEFGAKLRAQDDKIRQLTRENQXXXLHSHFLR D_simulans QECLQIEDRYSK-----------AQNISKEFGAKIRAQDDKIRQLTRENQXXXLHSHFLR D_erecta QECMQIEDRYSK-----------AQNISKEFGAKIRAQDDKIRQLTRENQXXXLRSHFLR D_yakuba QECLQIEDRYSK-----------AQNMSKEFGAKLRAQDDKLRQLTRENQ--FLRSHFLR D_melanogaster QECMQIEDRYSK-----------AQNISKEFGAKLRAQDDKIRQLSRENQ--FLRTHLLR D_ananassae QECLAIEDRYSK-----------AQNVSKEFGAKIRALEDKIRQLSRENQXXXIRSHYLR D_persimilis QECLQIEDRYSK-----------AQNISKEFGAKIRALDEKMRQLTRENQXXXLRSHFLR D_pseudoobscura QECLQIEDRYSK-----------AQNISKEFGAKIRALDEKMRQLTRENQ--FLRSHFLR D_willistoni QECLQIEDRYSK-----------AQNVSKECGAKVRSLEDKLRQLTRENQXXXLRSHFLR D_grimshawi QECLQVEDRYSKDQGRQRQQSLNAQNISKEYGVKIRALEEKIRELTRENHXXXLRSHIIR D_virilis QECLQIEDRYSKDQGRQRQQSLNAQNISKEFGAKIRALEEKIRELTRENQXXXLRLNIIR D_mojavensis QECLQIEDRYAKDQGRQRQLSLNAQNISKEFGAKIRALEEKIRDLTRENQXXXLRSHMIR Bombyx QEYLLLEAKFENLVKR-----TERSKMKRMEEDKDNSTDRDASIADK---------DSMV Phlebotomus QEYLQLEANFEMVSKR-----LTRETNQRHADAKEQMLQRNNYEFQNRIRSLEEQIDRLT Anopheles QEYIKLAIEY-------------------------------------------------- Aedes QEYLQLEANYEQVMRR-----YNAVKSLS-----IREENESAVNNATMTTKDAIEGGVAL Culex QEYLQLEANFEQVTRR-----FAAKPAAGGGAASAREENESSVN--AIEVGGGGGGGRRL Nasonia_vitripennis QEYIQLEAKVDLL----------TKRLRSKSGQQQQQQQESAEASEPSRDSETAKKLKVC Nasonia_girault QEYIQLEAKVDLL----------TKRLRSKSSQQQQQQQESAEASEPSR----------- Apis QEYLQLEAKVDLL----------TKRLRGKNFHQTEQRD--LESNSSSTDSESAKKLKIC Acyrthosiphon QRVIELEEKIQMQ----------ESNKR-------------------------------- Tribolium QEYLMLESKLELL----------TKRQRKREVTSTSSSVELQSEVERLT----------- Pediculus HDYLQLESKYEKT----------LIELKRLKKVGNDEVEGSVQDNDTNE----------- Brugia REYMHLEKINGKL------------------ADRVSFLQL-------------------- Ascaris SIHQCLHFILFMC------------------AHRST------------------------ Ancyclostoma REILDKEKNAELY------------------QENMSRMMK-------------------- Haemonchus XXILDKEKNAELY------------------QENMSKMMK-------------------- C_elegans AELLERDQDTQVL------------------TRELGSKET-------------------- C_remanei AELLERDQDTQQL------------------ARELGSKES-------------------- C_brenneri AELLERDQDTQLL------------------ARELGSKES-------------------- C_briggsae AELLERDQDTQEL------------------TRELGTKES-------------------- C_japonica QELLERDQDTQLL------------------TQELDTMDA-------------------- Aplysia KHYMSLEEKVESL------------------QKEMAVVKQ-------------------- Reniera SQCCNLEDKVSVIE-----------------QEKMELLSQ-------------------- Trichoplax RYCYQLDKKIQQL------------------EEADQDATN-------------------- Lottia -------------------------------LRADENSDGTS--------LSSSGEELQD Crassostrea -------------------------------INDTADDSSAS--------LSTGGKEFVD Saccoglossus --------------------------------QRDKESRLTE--------KRSSDDELLA Ciona_intestinalis ------------------KMQT--VQEQLEALQQENERLVKE--------NVRLRFGDEG Ciona_savignyi ------------------CRT--------------------------------------- Hydra -------------------------------LKEENYKLLQE--------IKDLKAEKAK Nematostella -------------------------------LYSMNKDARTG--------VWGLECDPVI Capitella -----------------------------SELQAEIQRLTEE--------NSWLRRENGI Branchiostoma ------------------KTTSPVGNGRESELRREVERLRQE--------NAKLQAENTL Taeniopygia -------------------ESKKAGGEA--ADPARVQALERE--------VDRLRAENLR Gallus -------------------ESKKHG-EA--AEAAR--LLEIE--------VDRLRAENLQ Anolis -------------------ENKKFSGDS--TEDPRVSQLEQE--------LDRLRAENQK H1_Bos -------------------ESQRLDG-----DDARVRELELE--------LDRLRAENLQ H1_Sus -------------------ESKRLGGG----DDARVRELELE--------LDRLRAENLQ H1_Pan -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Homo -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Pongo -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Macaca -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Canis -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Felis -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Equus -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Erinaceus -------------------ESKRLGG-----DDARVRELELE--------LDRLRAENLQ H1_Microcebus -------------------ESKRLGS-----DDARVRELELE--------LDRLRAENLQ H1_Otolemur -------------------ESKRLGS-----DDARVRELELE--------LDRLRAENLQ H1_Myotis -------------------ESKRLGGG---GDDARVRELELE--------LDRLRAENLQ H1_Rattus -------------------ESKRLGG-----VDARVRELELE--------LDRLRAENRQ H1_Mus -------------------ESKRLGG-----VDARVRELELE--------LDRLRAENLQ H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus -------------------ESKRPGD------DARVRELELE--------LDRLRAENLQ H1_Monodelphis -------------------ESKKFG------EDSRVRELELE--------LDRLKAENLQ H1_Sorex -------------------ESKRPG------EDARVRELELE--------LE-------- H1_Cavia -------------------ESRRPGG-----DEARVRELELE--------LDRLRAENLR Ornithorhynchus ------------------------------------------------------------ H2_Bos -------------------LRGCTNWRP----CYQVEELAAE--------VERLRTENQR H2_Canis -------------------LRGYTSQQP----CCQVEELAAE--------VERLRTENLR H2_Equus -------------------LQGCISRQP----CRQVEELAAE--------VERLRTENQR H2_Erinaceus -------------------LQGNTCQQP----CRQVEELAAE--------VERLRTENQR H2_Homo -------------------LQACTGQQS----CRQVEELAAE--------VQRLRTENQR H2_Pan -------------------LQACTGQQS----CRQVEELAAE--------VQRLRTENQR H2_Pongo -------------------LQACTGQQS----CRQVEELAAE--------VERLRTENQR H2_Macaca -------------------LQACTGQQS----CRQVEELAAE--------VERLRTENQR H2_Microcebus -------------------LQVCTGQQP----CRQVEELAAE--------VERLRTENQR H2_Dasypus -------------------LQGGTRQQS----CRQVEELAAE--------IERLRTENQR H2_Myotis -------------------LQGRTSRQS----CRQVEELAAE--------VERLRTENQR H2_Rattus -------------------LQGRPSRQP----CQQVEELAAE--------VERLRTENQR H2_Mus -------------------LQGCSSRQP----CQQVEELAAE--------VERLRTENQR H2_Felis -------------------LRGCTGPQP----CRQVEELAAE--------VERLRTENQR H2_Ochotona -------------------LQGRSGQWH----CRHVEELAAE--------VERLRTENQR H2_Oryctolagus -------------------LQGSTGQWR----CRHVEELAAE--------VERLRTENQR H2_Spermophilus -------------------LQGRMGQQP----CRQVEELAAE--------VERLRTENQR H2_Tupaia -------------------LQACTGQQS----CRQVEELAAE--------VERLRTENQR H2_Loxodonta ------------------------------------------------------------ H2_Otolemur -------------------XXXXXXXXX----XXXXXXXXXX--------XXXXXXXXXX H2_Echinops -----------------------DYQEL----ERRLSQAEEE--------MRRLQQLQRA H2_Sorex ------------------------------------------------------------ H2_Monodelphis -------------------QRDPLGPHP----CHRAQELAAE--------VERLKMENQR Tetraodon -------------------AAE-PGALTPESCLLRLGELEKE--------LERLRAQNSE Takifugu -------------------AVE-HGGLTPESSLVRLGELERE--------LETLRAQNSE Gasterostreus -------------------AAE-PGGVTAEGSLVRLRELERE--------LERLRAQNTQ Oryzias -------------------AVE-PGAAT-ESVQVRLQELEVE--------LERLRAENSE Danio -------------------VRRNPESPADGTGSQRVRELEVE--------VEKLRAENNE Xenopus_laevis -------------------VQSLASAPAADHRDTRIQELQVE--------LEKLKEENQR Xenopus_tropicalis -------------------LQSLTSTPVADH----------------------------- Callorhinchus -----RLEATDPRPGLGSGLALGLEPELQEEEEEEEKERERE----VQREVERLRAENRR Petromyzon SRHQAPLAAAAAPSSLRSPPAAEIAPVAVTQQQQQRDEQSTEGPPCAASSGGGVEDPSRG Strongylocentrotus --------------------GGGEGKLSSEESEGHLDDATRSR----LQSVNELEEKVEK Ixodes -----------------ARVDAHTQTAPDPEQAQKLAVFRDE--------IRKLADENAL Trichinella -----------------AVSELAKRCSTCGHNDVTPPPPPPQ--------LVGLADGEEH D_sechellia SCPATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPMDSTSED D_simulans SCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPMDSTSED D_erecta SCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPMDSSSED D_yakuba SCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPMDSSSED D_melanogaster TCSATAG---PAAAAAAAASPPSAVAPTPSSACELQARQQPPQQPQ----PTPMDSTSED D_ananassae SCPTSAG---PAAAAAAAASPPSAVAPTPSSARELQARQQPPQQPQELLQPTPMDSSSED D_persimilis SCSAAAG---PAAAAAAAASPPSAVAPTASSACELQARQQPAQQQP-----TPMDSSSED D_pseudoobscura SCSAAAG---PAAAAAAAASPPSAVAPTASSACELQARQQPAQQQP-----TPMDSSSED D_willistoni SCSTPPGGPAVAAAAAAAASPPSAAAPTPSSASELQARQQPPNQQQ----PTPMDSSSED D_grimshawi SRSPTTT-----AAAAAAASPPSAAAPTASAVCELQARQQP-QQPP-----TPMDSSSED D_virilis SCSPTIT-----AAAAAAASPPSAAAPTASAVCELQARQHP-LQP------TPMDSSSED D_mojavensis PRSPTLL-----VGIAAAASPPSASAPTASAVCELEARQQP-QEP------TPMDSSSED Bombyx TDRDTSE---TSVETFTAEDPPSNEIWQRLKDQEDQIRELQISNEKLLLENEHLRQRQHN Phlebotomus EDNIDLS---RQLEFYRSNAPPPASAGMICSSSEDSESDSSSSSSSSSSSSSDDQILCTV Anopheles ------------------------------------------------------------ Aedes AAAAAAP---VAAATDRRRLEDRIRELTAENLGKCERYGRTL------------------ Culex EDRIREL---TAENLELRRQLEHASRIGMVLSAKSSPRPHAAGGAGVERMDSSSCSSSED Nasonia_vitripennis QQRVDEL-------------------LQQNEQLRRENELLRKQRHGSPMSSVDSESDSDS Nasonia_girault -----------------------------TARLPR---------------------SSRS Apis QQRIDDL-------------------MQQNEQLKRENELLRAKRDGSPVSSVDSESDSDS Acyrthosiphon ------------------------------------------------------------ Tribolium ---------------------------IENEALKRENAALR---------SKTCSSDSED Pediculus ----------------------------------------------------NGEKEEQD Brugia -------------------------------ENDKLKQXLKD---------XNISYEDVL Ascaris ------------------------------------------------------------ Ancyclostoma -------------------------------ENQRLRKMLQD---------NGIPVDHNH Haemonchus -------------------------------ENQRLRKMLID---------NGIVLGENH C_elegans -------------------------------ENRHLRSLLSA---------HGISPDEPV C_remanei -------------------------------ENQHLRKLLYA---------HGISPDEPV C_brenneri -------------------------------ENRHLRNLLSA---------HGISPDEPV C_briggsae -------------------------------ENRHLRKLLTA---------HGISPDEPV C_japonica -------------------------------ENRHLRRLLTA---------HGIHLESPP Aplysia ---------------------------------RKLDRAS-------------------- Reniera --------------------------------------------------LHQLKKANGM Trichoplax -------------------------RDSNHHHHSNETKIGNDD-------VEQMQKEIAS Lottia LAALKNVGEEMKRLREDNIKMKEQIEELKKKNGGF------------------------- Crassostrea MDVVR--------------KLEAEHED--------------------------------- Saccoglossus VN---------------------------------------------------------- Ciona_intestinalis VDTLRTSDYEYEAPNSDQSDDESKISMSVNGGIQPPNGAIELFSLPLKEAAQSSVESMVV Ciona_savignyi ------------------------------------------------------------ Hydra N----------------------------------------------------------- Nematostella CS---------------------------------------------------------- Capitella LKGIKTGEATEC------------------------------------------------ Branchiostoma LKQGRQNSAPEA------------------------------------------------ Taeniopygia LLREQELPRQ-EKGPCKPGE---------------------------------------- Gallus LLRERDVRAA-EAAPE-------------------------------------------- Anolis LLKENELGRQQEKSVSKLGE---------------------------------------- H1_Bos LLTENELHRQQERAPLSNFGD--------------------------------------- H1_Sus LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Pan LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Homo LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Pongo LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Macaca LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Canis LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Felis LLSENELHRQQERAPLSKFGD--------------------------------------- H1_Equus LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Erinaceus LLTENELHRQQEQAPLSKFGD--------------------------------------- H1_Microcebus LLSENELHRQQERAPLSKFWRL-------------------------------------- H1_Otolemur LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Myotis LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Rattus LLTENELHRQQERAPPSKFGD--------------------------------------- H1_Mus LLTENELHRQQERAPLSKFGD--------------------------------------- H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus LLTENELHRQ-ERAPLSKFGD--------------------------------------- H1_Monodelphis LLKENELHRQQERAPLSKFGD--------------------------------------- H1_Sorex ------------------------------------------------------------ H1_Cavia LLRQSERPRAPEQD---------------------------------------------- Ornithorhynchus ------------------------------------------------------------ H2_Bos LRQENEMWNREGGRR-GGQPGS-------------------------------------- H2_Canis LRQENAMWNREGSRG-KGEPDT-------------------------------------- H2_Equus LRQENEMWNREGSRH-NGEPGT-------------------------------------- H2_Erinaceus LRQENEMWNREGSRQ-GGELGT-------------------------------------- H2_Homo LRQENQMWNREGCRC-DEEPGT-------------------------------------- H2_Pan LRQENQMWNREGCRC-DEEPGT-------------------------------------- H2_Pongo LRQENQMWNREGCRC-DEEPGT-------------------------------------- H2_Macaca LRQENQMWNREGCCC-DEEPGT-------------------------------------- H2_Microcebus LRQENEMWNRE------------------------------------------------- H2_Dasypus LRQENEMWIREGGSR-SMDPGT-------------------------------------- H2_Myotis LRQENEMWNQEGGQAPRGAPSPV------------------------------------- H2_Rattus LRQENEMWNREGSYCDREKTAAEGTPRPKDEAPLQTRSGQLGHREAGDR----------- H2_Mus LRQENEMWNREGGYCDQEKPASEGTPWPKVEAPFQTHTGQLGHREAGDR----------- H2_Felis LRQENEMWNRKGSCP-GGESGT-------------------------------------- H2_Ochotona LRQENQMWHPGEGP-----GTEECPPRQMDPRPAGSQGGW-------------------- H2_Oryctolagus LRQENQMWIRRGSPRDDELGTEECLPRQMDPRPAGSHGGR-------------------- H2_Spermophilus LRQEKEMWNQGGSRR-HEEPGT-------------------------------------- H2_Tupaia LRQENEMWNREGNRR-GEEPGT-------------------------------------- H2_Loxodonta ------------------------------------------------------------ H2_Otolemur XXXXXXXXXRDYLELEKARVSQAEE----------------------------------- H2_Echinops ASQQPSRQWRS------------------------------------------------- H2_Sorex ------------------------------------------------------------ H2_Monodelphis LRRENEMWGQGGNSP-NGDVGT-------------------------------------- Tetraodon LLLQKQP----------------------------------------------------- Takifugu LLLLNQPNKDREQVASN------------------------------------------- Gasterostreus LLLQSQPSEDRGQVGSN------------------------------------------- Oryzias LHLQSKLSRDQDQGAAQ------------------------------------------- Danio LLLKTPASNEPGLNQSQPS----------------------------------------- Xenopus_laevis LLQEGKQVAADSP----------------------------------------------- Xenopus_tropicalis ------------------------------------------------------------ Callorhinchus LEEENELSHRGRGGEGECGLGSPNPASCRSASSNLQD----------------------- Petromyzon EGGSLAKSHHTHAGGAGDALGKQLVVDLQAEVERLQRENGRLAHQNELLQQQQPPPEANV Strongylocentrotus LKEENKRLRTASYTDKE------------------------------------------- Ixodes VRAQNRALREALDPGPS------------------------------------------- Trichinella QQNGHST----------------------------------------------------- D_sechellia SESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS---RSPI D_simulans SESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS---RSPI D_erecta SESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS---RSPI D_yakuba SESDSSSTTSSTTSSTSSS-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS---RSPI D_melanogaster SESDSSSTTSSTTSTTSST-SSDGHEMGVAGLNIANGHAER--HERSRTRSRS---RSPI D_ananassae SESDSSSSTSSTSSNSSSS-SSDGHEMGVAGLNIANGHAER--HDKSRSRSRS---RSPI D_persimilis SESDSSSTTSSTTSSTTSN-SSDAHEMGVAGLNIANGHVERSIHEGRGSRSRS---RSPI D_pseudoobscura SESDSSSTTSSTTSSTTSN-SSDAHEMGVAGLNIANGHAERSIHEGRGSRSRS---RSPI D_willistoni SESDSSSTTSSTTSSTTSSGSSDDHAMGVAGLNIANGHVERSAHSCSRSRSRS---RSPI D_grimshawi SESDSSSTTSSTTSSSSSS--SEGHEMGVAGLNIANGHAE-SHRHKSRSHSRSPILVIN- D_virilis SESDSSSSTSTTTSSSSSS--SEGHEMGVAGLNIANGHAERSVQRHSRSRSGSPALQIDA D_mojavensis SESDSSSSTSSTTSSSSST--SDGHEMGVAGLNIANGHAESRAHRHSRSHSRSPQLLIEA Bombyx SSEDSESDSSSTSDSNSSSGSEKVVDEPVVQNEPVNDIAQPNGCQEFE------------ Phlebotomus MRMMSHSSTQGPLCMATHIPVTATVHESITQWGLFAQFPQLH------------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex SESDSSSSSSSSSGGSSSSSMSEDEDDGDQDGRRRGELVEDRQPLVAMMDGGEGEPNGYH Nasonia_vitripennis SSNASGCSCNHKTSPGSSPVPASYHARREKTNSRRKNSSVSSVDSESDSTTGDSSCPDGS Nasonia_girault VSNAS----------------TSCFSRR---TAQRENECCASRA---------------- Apis TSNENRSRCSCLLPNSSSSSELMGYVSRSK-NSQRKDSSVSSTDSKSDTCDSSSS----- Acyrthosiphon ------------------------------------------------------------ Tribolium SETDSNDSCSSTSSSSSSCCSAEAPPSPVLDYSQTNGHSASVETV--------------- Pediculus RDTDTSSKSENEVAEQLRITQIENKSLKVELEELRKENKTSSAY---------------- Brugia PKIRRHSGTSVSEAGDVVRKSVDEAMGNGRQ----------------------------- Ascaris ------------------------------------------------------------ Ancyclostoma TSQPVV------------------------------------------------------ Haemonchus TSQSVV------------------------------------------------------ C_elegans TSTTAI----VVGQSKSPVVAN-------------------------------------- C_remanei TSTTTID---VVVGSKSPVIAN-------------------------------------- C_brenneri SSTTSS----IGNVSKSPVIAN-------------------------------------- C_briggsae TSSTTALQLNAVSASKSPVIAN-------------------------------------- C_japonica DDVTSSG---APCVDKSPVIA--------------------------------------- Aplysia ------------------------------------------------------------ Reniera VTESHRIYTHHMI----------------------------------------------- Trichoplax LRQENTKLYGLIASQKEKK----------------------------------------- Lottia ------------------------------------------------------------ Crassostrea ------------------------------------------------------------ Saccoglossus ------------------------------------------------------------ Ciona_intestinalis SSQSQLSHGARNEDYEADVASSEEKEVRERRKRSRNQREKDRVSKERRISKDGTSDEEEK Ciona_savignyi ------------------------------------------------------------ Hydra ------------------------------------------------------------ Nematostella ------------------------------------------------------------ Capitella ------------------------------------------------------------ Branchiostoma ------------------------------------------------------------ Taeniopygia ------------------------------------------------------------ Gallus ------------------------------------------------------------ Anolis ------------------------------------------------------------ H1_Bos ------------------------------------------------------------ H1_Sus ------------------------------------------------------------ H1_Pan ------------------------------------------------------------ H1_Homo ------------------------------------------------------------ H1_Pongo ------------------------------------------------------------ H1_Macaca ------------------------------------------------------------ H1_Canis ------------------------------------------------------------ H1_Felis ------------------------------------------------------------ H1_Equus ------------------------------------------------------------ H1_Erinaceus ------------------------------------------------------------ H1_Microcebus ------------------------------------------------------------ H1_Otolemur ------------------------------------------------------------ H1_Myotis ------------------------------------------------------------ H1_Rattus ------------------------------------------------------------ H1_Mus ------------------------------------------------------------ H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus ------------------------------------------------------------ H1_Monodelphis ------------------------------------------------------------ H1_Sorex ------------------------------------------------------------ H1_Cavia ------------------------------------------------------------ Ornithorhynchus ------------------------------------------------------------ H2_Bos ------------------------------------------------------------ H2_Canis ------------------------------------------------------------ H2_Equus ------------------------------------------------------------ H2_Erinaceus ------------------------------------------------------------ H2_Homo ------------------------------------------------------------ H2_Pan ------------------------------------------------------------ H2_Pongo ------------------------------------------------------------ H2_Macaca ------------------------------------------------------------ H2_Microcebus ------------------------------------------------------------ H2_Dasypus ------------------------------------------------------------ H2_Myotis ------------------------------------------------------------ H2_Rattus ------------------------------------------------------------ H2_Mus ------------------------------------------------------------ H2_Felis ------------------------------------------------------------ H2_Ochotona ------------------------------------------------------------ H2_Oryctolagus ------------------------------------------------------------ H2_Spermophilus ------------------------------------------------------------ H2_Tupaia ------------------------------------------------------------ H2_Loxodonta ------------------------------------------------------------ H2_Otolemur ------------------------------------------------------------ H2_Echinops ------------------------------------------------------------ H2_Sorex ------------------------------------------------------------ H2_Monodelphis ------------------------------------------------------------ Tetraodon ------------------------------------------------------------ Takifugu ------------------------------------------------------------ Gasterostreus ------------------------------------------------------------ Oryzias ------------------------------------------------------------ Danio ------------------------------------------------------------ Xenopus_laevis ------------------------------------------------------------ Xenopus_tropicalis ------------------------------------------------------------ Callorhinchus ------------------------------------------------------------ Petromyzon ME---------------------------------------------------------- Strongylocentrotus ------------------------------------------------------------ Ixodes ------------------------------------------------------------ Trichinella ------------------------------------------------------------ D_sechellia -LNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---------------------- D_simulans -LNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---------------------- D_erecta HLNGHANEEERQRLLDGNQMDEDDNSSDIPRPGDAVVK---------------------- D_yakuba HLNGHANEEERQRLLDGNQMDEDDNSSDVPRPGDAVVK---------------------- D_melanogaster HLNGHANEEERQRLLDGNQMEEDDNSSDVSRPADAVVK---------------------- D_ananassae HLNGHANEEERQALLDSNQMDEDDNSSDGIKQADADVK---------------------- D_persimilis HLNGHANEEERLRLLDPNPMDEDGNSSDEPKNGDATDK---------------------- D_pseudoobscura HLNGHATEEERLRLLDPNPMDEDGNSSDEPKNGDATDK---------------------- D_willistoni QLNGHANDEERSRLLDSNQMDDDENSNDGATNGNPATK---------------------- D_grimshawi ---GHANEEERLLLLDASRMEEDDNSSEDAKNNDAIDGAPK------------------- D_virilis QLNGHANEEERLLLLDASRMEEDDNSSEDAKNNDAVAGEPE------------------- D_mojavensis HQNGHANEEEQLLLLDASHMEEDDNSSEDAKNNDAVNGEPN------------------- Bombyx ------------------------------------------------------------ Phlebotomus ------------------------------------------------------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex QLNGVLEEDVIPLENGNGGDFNGAVSPLSAHSINSPPPLVMN------------------ Nasonia_vitripennis PKTSTGTTNTDVANGHATSHELDGLPI--------------------------------- Nasonia_girault ------------------------------------------------------------ Apis ENSKASMTPVNLSNGHVTIQKIDGLPT--------------------------------- Acyrthosiphon ------------------------------------------------------------ Tribolium ------------------------------------------------------------ Pediculus ------------------------------------------------------------ Brugia ------------------------------------------------------------ Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Aplysia ------------------------------------------------------------ Reniera ------------------------------------------------------------ Trichoplax ------------------------------------------------------------ Lottia ------------------------------------------------------------ Crassostrea ------------------------------------------------------------ Saccoglossus ------------------------------------------------------------ Ciona_intestinalis MNQKMLRSSNDVEGHSPNGEENNDKTDERSQRSENNGVNFKAKKLRKSDSCFMEVEQWEE Ciona_savignyi ------------------------------------------------------------ Hydra ------------------------------------------------------------ Nematostella ------------------------------------------------------------ Capitella ------------------------------------------------------------ Branchiostoma ------------------------------------------------------------ Taeniopygia ------------------------------------------------------------ Gallus ------------------------------------------------------------ Anolis ------------------------------------------------------------ H1_Bos ------------------------------------------------------------ H1_Sus ------------------------------------------------------------ H1_Pan ------------------------------------------------------------ H1_Homo ------------------------------------------------------------ H1_Pongo ------------------------------------------------------------ H1_Macaca ------------------------------------------------------------ H1_Canis ------------------------------------------------------------ H1_Felis ------------------------------------------------------------ H1_Equus ------------------------------------------------------------ H1_Erinaceus ------------------------------------------------------------ H1_Microcebus ------------------------------------------------------------ H1_Otolemur ------------------------------------------------------------ H1_Myotis ------------------------------------------------------------ H1_Rattus ------------------------------------------------------------ H1_Mus ------------------------------------------------------------ H1_Ochotona ------------------------------------------------------------ H1_Oryctolagus ------------------------------------------------------------ H1_Monodelphis ------------------------------------------------------------ H1_Sorex ------------------------------------------------------------ H1_Cavia ------------------------------------------------------------ Ornithorhynchus ------------------------------------------------------------ H2_Bos ------------------------------------------------------------ H2_Canis ------------------------------------------------------------ H2_Equus ------------------------------------------------------------ H2_Erinaceus ------------------------------------------------------------ H2_Homo ------------------------------------------------------------ H2_Pan ------------------------------------------------------------ H2_Pongo ------------------------------------------------------------ H2_Macaca ------------------------------------------------------------ H2_Microcebus ------------------------------------------------------------ H2_Dasypus ------------------------------------------------------------ H2_Myotis ------------------------------------------------------------ H2_Rattus ------------------------------------------------------------ H2_Mus ------------------------------------------------------------ H2_Felis ------------------------------------------------------------ H2_Ochotona ------------------------------------------------------------ H2_Oryctolagus ------------------------------------------------------------ H2_Spermophilus ------------------------------------------------------------ H2_Tupaia ------------------------------------------------------------ H2_Loxodonta ------------------------------------------------------------ H2_Otolemur ------------------------------------------------------------ H2_Echinops ------------------------------------------------------------ H2_Sorex ------------------------------------------------------------ H2_Monodelphis ------------------------------------------------------------ Tetraodon ------------------------------------------------------------ Takifugu ------------------------------------------------------------ Gasterostreus ------------------------------------------------------------ Oryzias ------------------------------------------------------------ Danio ------------------------------------------------------------ Xenopus_laevis ------------------------------------------------------------ Xenopus_tropicalis ------------------------------------------------------------ Callorhinchus ------------------------------------------------------------ Petromyzon ------------------------------------------------------------ Strongylocentrotus ------------------------------------------------------------ Ixodes ------------------------------------------------------------ Trichinella ------------------------------------------------------------ D_sechellia ------------------------------------------------------------ D_simulans ------------------------------------------------------------ D_erecta ------------------------------------------------------------ D_yakuba ------------------------------------------------------------ D_melanogaster ------------------------------------------------------------ D_ananassae ------------------------------------------------------------ D_persimilis ------------------------------------------------------------ D_pseudoobscura ------------------------------------------------------------ D_willistoni ------------------------------------------------------------ D_grimshawi ------------------------------------------------------------ D_virilis ------------------------------------------------------------ D_mojavensis ------------------------------------------------------------ Bombyx ------------------------------------------------------------ Phlebotomus ------------------------------------------------------------ Anopheles ------------------------------------------------------------ Aedes ------------------------------------------------------------ Culex ------------------------------------------------------------ Nasonia_vitripennis ------------------------------------------------------------ Nasonia_girault ------------------------------------------------------------ Apis ------------------------------------------------------------ Acyrthosiphon ------------------------------------------------------------ Tribolium ------------------------------------------------------------ Pediculus ------------------------------------------------------------ Brugia ------------------------------------------------------------ Ascaris ------------------------------------------------------------ Ancyclostoma ------------------------------------------------------------ Haemonchus ------------------------------------------------------------ C_elegans ------------------------------------------------------------ C_remanei ------------------------------------------------------------ C_brenneri ------------------------------------------------------------ C_briggsae ------------------------------------------------------------ C_japonica ------------------------------------------------------------ Aplysia ------------------------------------------------------------ Reniera ------------------------------------------------------------ Trichoplax ------------------------------------------------------------ Lottia ------------------- Crassostrea ------------------- Saccoglossus ------------------- Ciona_intestinalis KRPSTASMESLTSCSNTTN Ciona_savignyi ------------------- Hydra ------------------- Nematostella ------------------- Capitella ------------------- Branchiostoma ------------------- Taeniopygia ------------------- Gallus ------------------- Anolis ------------------- H1_Bos ------------------- H1_Sus ------------------- H1_Pan ------------------- H1_Homo ------------------- H1_Pongo ------------------- H1_Macaca ------------------- H1_Canis ------------------- H1_Felis ------------------- H1_Equus ------------------- H1_Erinaceus ------------------- H1_Microcebus ------------------- H1_Otolemur ------------------- H1_Myotis ------------------- H1_Rattus ------------------- H1_Mus ------------------- H1_Ochotona ------------------- H1_Oryctolagus ------------------- H1_Monodelphis ------------------- H1_Sorex ------------------- H1_Cavia ------------------- Ornithorhynchus ------------------- H2_Bos ------------------- H2_Canis ------------------- H2_Equus ------------------- H2_Erinaceus ------------------- H2_Homo ------------------- H2_Pan ------------------- H2_Pongo ------------------- H2_Macaca ------------------- H2_Microcebus ------------------- H2_Dasypus ------------------- H2_Myotis ------------------- H2_Rattus ------------------- H2_Mus ------------------- H2_Felis ------------------- H2_Ochotona ------------------- H2_Oryctolagus ------------------- H2_Spermophilus ------------------- H2_Tupaia ------------------- H2_Loxodonta ------------------- H2_Otolemur ------------------- H2_Echinops ------------------- H2_Sorex ------------------- H2_Monodelphis ------------------- Tetraodon ------------------- Takifugu ------------------- Gasterostreus ------------------- Oryzias ------------------- Danio ------------------- Xenopus_laevis ------------------- Xenopus_tropicalis ------------------- Callorhinchus ------------------- Petromyzon ------------------- Strongylocentrotus ------------------- Ixodes ------------------- Trichinella ------------------- D_sechellia ------------------- D_simulans ------------------- D_erecta ------------------- D_yakuba ------------------- D_melanogaster ------------------- D_ananassae ------------------- D_persimilis ------------------- D_pseudoobscura ------------------- D_willistoni ------------------- D_grimshawi ------------------- D_virilis ------------------- D_mojavensis ------------------- Bombyx ------------------- Phlebotomus ------------------- Anopheles ------------------- Aedes ------------------- Culex ------------------- Nasonia_vitripennis ------------------- Nasonia_girault ------------------- Apis ------------------- Acyrthosiphon ------------------- Tribolium ------------------- Pediculus ------------------- Brugia ------------------- Ascaris ------------------- Ancyclostoma ------------------- Haemonchus ------------------- C_elegans ------------------- C_remanei ------------------- C_brenneri ------------------- C_briggsae ------------------- C_japonica ------------------- Aplysia ------------------- Reniera ------------------- Trichoplax -------------------