CLUSTAL W (1.83) multiple sequence alignment Dm_Vegfr FEFPRENLKLGKQLGAGAFGVVLKGEAKGIRRE-EPTTTVAVKMVKATADNEVVRALVSELKIMVHLGQHLNVVNLLGAVTKNIAKRELMVIVEYCRFGNIQNFLV Hs_Flt3_13 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKT-GVSIQVAVKMLKEKADSSEREALMSELKMMTQLGSHENIVNLLGACTL---SGPIYLIFEYCCYGDLLNYLL Gg_Flt3_1 WEFPRENLEFGQVLGSGAFGKVVNATAYGISKA-GDSVQVAVKMLKEKSDTSEKDALMSELKMMTHIGSHENIVNLLGACTV---SGPIYLIFEYCCYGDLLNYLL Xt_flt3_S449 WEFPRENLEFGKVLGSGAFGRVVTATAYGITKP-GVSLQVAVKMLKENADGSEKDALMSELKMMTQIGHHQNIVNMLGACTAAATTGPVYLIFEYCRHGDLLNYLL Dr_flt3_S2411 WEFPRENLELGNELGSGAFGMVVQATAYGISKP-GVSVQVAVKMLKEKHQAVEKEALMSELKMLTHIGHHENIVNLLGACTG---SGPIYLIFQFCCNGDLLNYLK Dr_flt3_24 WEFPRENLELGNELGSGAFGMVVQATAYGISKP-GVSVQVAVKMLKEKHQAVEKEALMSELKMLTHIGHHENIVNLLGACTG---SGPVYLIFQYCCNGDLLNYLK Tr_flt3_S146 WEFPRENLELGKELGSGAFGMVVQATAYGISKP-GVPQQVAVKMLKEKHHSVEKEALVSELKMLTHIGSHDNIVNLLGACTE---SGPTYLIFQYCCHGDLLNYLK Tn_flt3_6 WEFPRENLELGKELGSGAFGMVVQATAYGINKP-GVPQQVAVKMLKEKHQSVEKEALMSELKMLTHIGHHDNIVNLLGACTESLQAGPTYLIFQYCCYGDLLNYLK Cf_Flt3_25 WEFPRENLEFGKVLGSGAFGKVMNATAYGISKT-GVSIQVAVKMLKEKADSSEREALMSELKILTHIGHHLNVVNLLGACTK--QGGPLMVIVEYCKYGNLSNYLL Xt_flt4_S10 WEFPRDRLRLGKVLGHGAFGKVVEASAFGMSKS-SSCETVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--SNGPLMVIVEFCKYGNLSNYLL Cf_Flt4_11 WEFPRERLHLGRVLGHGAFGKVVEASAFGIHKG-SSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEFCKYGNLSNFLL Hs_Flt4_5 WEFPRERLHLGRVLGYGAFGKVVEASAFGIHKG-SSCDTVAVKMLKEGATASEHRALMSELKILIHIGNHLNVVNLLGACTK--PQGPLMVIVEFCKYGNLSNFLL Gg_Flt4_p_13 --------------------KVVEASAFGINKS-NSCETVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVIVEFCKYGNLSNYLR Tr_flt4_S663 WEVSRDRLRLGKVLGHGAFGKVMEASICGIKKG-SSLDTVAVKMLKDGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--PNGPLMVVVEYCKYGNLSNFLR Tn_flt4_1-2M WEVSRDRLRLGKVLGHGAFGKVMEASIRGIDKGGSSLDTVAVKMLKDGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--ANGPLMVVVEYCKYGNLSNYLR Dr_flt4_23 WEISRDRLRLGKVLGHGAFGKVIEASIFGHDKK-SSANTVAVKMLKEGATASEHKALMSELKILIHIGNHLNVVNLLGACTK--PN-------------------- Gg_Kdr_4 WEFPRDRLRLGKTLGHGAFGKVVEASAFGIDKS-STCKTVAVKMLKECATTNECKALMSELKILIHIGHHLNVVNLLGACTK--AGGPLMVIVEYCKYGNLSNYLL Xt_kdr_S69 WEFPRDRLSLGKTLGHGAFGKVVEASAFGIDKS-STCKTVAVKMLKECATNNERKALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEYCKYGNLSNYLL Tn_kdr_1-8M WEFPRDRLQLGKTLGHGAFGKVVEASAFGIDKM-STCKTVAVKMLKGGATSNERKALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMMIVEFCKYGNLSNYLR Tr_kdr_S598 WEFPRDRLQLGKTLGHGAFGKVVEASAFGIDKM-STCKTVAVKMLKGGATSNERKALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMMIVEFCKYGNLSNYLR Dr_kdr_14 WEFPQDRLRLGKTLGHGAFGKVVEASAFGIDKI-STCKTVAVKMLKVGATNNEWRALMSELKILIHIGHHLNVVNLLGACTK--RGGPLMIIVEFCKYGNLSNYLR Gg_Flt1_1 WEIARERLKLGKSLGHGAFGKVVQASAFGIKKS-PTCRIVAVKMLKEGATASEYKALMTELKILIHIGHHLNIVNLLGACTKN--GGPLMVIVEYCKYGNLSNYLL Hs_Flt1_13 WEFARERLKLGKSLGRGAFGKVVQASAFGIKKS-PTCRTVAVKMLKEGATASEYKALMTELKILTHIGHHLNVVNLLGACTK--QGGPLMVIVEYCKYGNLSNYLI Cf_Kdr_13 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT-ATCKTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLL Hs_Kdr_4 WEFPRDRLKLGKPLGRGAFGQVIEADAFGIDKT-ATCRTVAVKMLKEGATHSEHRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEFCKFGNLSTYLL Tn_kdr_1rnd WEFPRDRLKLGDPLGRGAFGQVVEAAAFGIEKA-TTCTTVAVKMLKEGATSSEFRALMSELKILIHIGHHLNVVNLLGACTK--PGGPLMVIVEYCKHGNLSSYLK Tr_kdr_S827 WEFPRDRLKLGDPLGRGAFGQVVEAAAFGIEKA-TTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTK--AGGPLMVIVEYCKHGNLSSYLK Dr_kdr_20 WEFPRDRLKLGEPLGRGAFGQVVEATAYGIEKA-TTCTTVAVKMLKEGATSSEYRALMSELKILIHIGHHLNVVNLLGACTK--QGGPLMVIVEYCKHGNLSSYLK Xt_kdr_S248 ---------------------VLEADAFGIDKS-GSCKTVAVKMLKEGATTSEHSALMSELKILSHIGHHLNVVNLLGACTK--PGGPLMVIVEYCKNGNLSAYLL Tr_flt1_S146 WEFPRERLKLGKPLGCGAFGKVMQASAFGIDNA--SCSTVAVKMLKEGATASEHKALMTELKILNHIGHHLNVVNLLGACTK--PGGPLMVIVEYCRYGNLSTFLK Tn_flt1_6 WEFPRERLKLGKPLGCGAFGKVMQASAFGLDSG--SCSTVAVKMLKEGATASEHKALMMELKILNHIGHHLNVVNLLGACTK--PGGPLMVIVEYCRHGNLSAFLK Dr_flt1_24 WEFPRDRLKLEKPLGRGAFGRVMQASAVGIGNS-ASCTTVAVKMLKDGATPSEHKALMTELKILNHIGHHINVVNLLGACTK--SGGPLMVIVEYCQFGNLSAYLK Cf_Csf1r_4 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE-DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH---GGPVLVITEYCCYGDLLNFLL Hs_Csf1r_5 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE-DAVLKVAVKMLKSTAHADEKEALMSELKIMSHLGQHENIVNLLGACTH---GGPVLVITEYCCYGDLLNFLL Gg_Csf1r_p_13 WEFPRNNLQFGKTLGAGAFGKVVEATAFGLGKE-DSVLKVAVKMLKSTADTDEQEALMSELKIMSHLGHHANIVNLLGACTY---GGPILVITEYCRYGDLLNFLR Xt_csf1r_S635 WEFPRTNLQFGKTLGAGAFGKVMEATAVGLGNE-DSAVTVAVKMLKPSAHTDEVEALMSELKILSHLGNHKNIVNLLGACTH---GGPILVITEYCHYGDLLNFLL Cf_Kit_13 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS-DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTV---GGPTLVITEYCCYGDLLNFLL Hs_Kit_4 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLIKS-DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHMNIVNLLGACTI---GGPTLVITEYCCYGDLLNFLL Gg_Kit_4 WEFPRNRLSFGKTLGAGAFGKVVEATAYGLFKS-DAAMTVAVKMLKPSAHLTEREALMSELKVLSYLGNHINIVNLLGACTI---GGPTLVITEYCCYGDLLNFLL Xt_kit_S248 WEFPRDRLCFGKILGAGAFGKVVEATAYGLIKE-DSRMTVAVKMLKPSAHSTEREALMSELKVLSYLGHHKNIVNLLGACTI---GGPTLVITEYCCYGDLLNYLL Tn_kit_1rnd WEFPRKNLRFGKTLGSGAFGKVVEATAYGLASA-DSTMTVAVKMLKSSAHSTEKEALMSELKVLIYLGNHINIVNLLGACTV---GGPTLVITEYCCFGDLLNFLR Tr_kit_S827 WEFPRKNLRFGKTLGSGAFGKVVEATAYGLANE-DSMMTVAVKMLKSSAHSTEKEALMSELKVLIYLGNHINIVNLLGACTV---GGPTLVITEYCCFGDLLNFLR Tr_Tk_wn03_S8076 WEFPRQKLRFGKTLGSGAFGKVVRATAYGLCSA-DTVSTVAVKMLKPNAHATEKEALMSELKVLTYLGNHVNIVNLLGACTV---AGPILVITEYCCYGDLLNFLR Tn_kit_18 WEFPRQKLRFGKTLGSGAFGKVVRATAYGLCSA-DTVTTVAVKMLKPNAHSTEKEALMSELKVLTYLGNHMNIVNLLGACTLGDHFGPILVITEYCCYGDLLNFLR Dr_kit_1 WEFPRERLRFGKILGSGAFGKVVAATAYGLCSA-DTVTTVAVKMLKPSAHSTEKEALMSELKVLSYIGNHINIVNLLGACTV---GGPTLVITEYCCYGDLLNFLR Tr_csf1r_S1324 WEFPRDKLKLGKVLGAGAFGKVVEATAFGLGEDKDNTLRVAVKMLKANAHSDEREALMSELKILSHLGHHQNIVNLLGACTY---GGPVLVITEYCSLGDLLNFLR Tn_csf1r_1-0M WEFPRDKLKLGKVLGAGAFGKVVEATAFGLGEDKDNTMRVAVKMLKVNAHSDEREALMSELKILSHLGHHQNIVNLLGACTY---GGPVLVITEYCSLGDLLNFLR Tr_Tk_wn02_S525 WEFPRDKLRLGAVLGSGAFGKVVEATAYGLGTD--DVTRVAVKMLKPRALSEEREALMSELKILSHLGYHDNIVNLLGACTQ---GGPMLMITEYCSYGDLLNFLR Tn_csf1r2_7 WEFPRDKLRLGAILGSGAFGKVVEATAYGLGTN--DVTRVAVKMLKPRAHSEEREALMSELKILSHLGYHDNIVNLLGACTQ---GGPMLMITEYCSYGDLLNFLR Cf_Pdgfra_13 WEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLL Gg_Pdgfra_4 WEFPRDGLVLGRILGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLL Xt_pdgfra_S248 WEFQRDGLVLGRILGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGAHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLL Dr_pdgfra_20 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLH Hs_PdgfrA_4 WEFPRDGLVLGRVLGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLL Tn_pdgfra_1rnd WEFPRDRLVLGRILGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLH Tr_pdgfra_S827 WEFPRDRLVLGRILGSGAFGKVVEGTAYGLSRS-QPVMKVAVKMLKPTARSSEKQALMSELKIMTHLGPHLNIVNLLGACTK---SGPIYIITEYCFYGDLVNYLH Cf_Pdgrfb_4 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHS-QATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTK---GGPIYIITEYCRYGDLVDYLL Hs_PdgfrB_5 WELPRDQLVLGRTLGSGAFGQVVEATAHGLSHS-QATMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNVVNLLGACTK---GGPIYIITEYCRYGDLVDYLL Gg_Pdgfrb_p_13 WEVPRDKLVLGRTLGSGAFGRVVEATAHGLSHS-QSTMKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNIVNLLGACTK---GGPIYIITEYCRYGDLVDYLH Xt_pdfgrb_S635 WELPRDKLVLGRTLGSGAFGRVVEATAHGLGHA-QSVTKVAVKMLKSTARSSEKQALMSELKIMSHLGPHLNIVNLLAACTK---GGPVYIITEYCRYGDLVDYLL Tn_pdgfrb_1-0M WEMSRDNLVLGRTLGSGAFGRVVEATAYGLMHS-QSSIKVAVKMLK--SRESETQALMSELKIMSHLGPHLNIVNLLAACTKHNQSGPLYLVTEYCRYGDLVDYLH Tr_pdgfrb_S1324 WEMPRDNLVLGRTLGSGAFGRVVEATAHGLSHS-QSSIKVAVKMLKATARRSETQALMSELKIMSHLGPHLNIVNLLAACTK---HGPLYLVTEYCRYGDLVDYLH Tr_Tk_wn01_S525 WEVPRDNISLGPVLGSGAFGRVVEANVSGLLHS-HSTTKVAIKMVK--SNSGAVQSLMSELKVLVHLGPHLNIVNLLGACTR---GGPVYLITEFCRHGDLVSYLE Tn_pdgfrb2_7 WEVPRDNIVLGQVLGSGVFGRVVEANVSGLLHS-HSTTKVAVKMVKGAGNSGAVQSLMSELKVLVHLGPHLNIVNLLGACTR---KGPVYLITEFCRHGDLSGYLE *: . * **:**:* :*: ***:: :* * *:**:*.* *